Ketamine may reduce heavy drinkers' craving

It may help to change habits and memories linked to alcohol, researchers believe.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news

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Publication date: 15 January 2020Source: Life Sciences, Volume 241Author(s): Ekaterina Veniaminova, Margarita Oplatchikova, Lucien Bettendorff, Elena Kotenkova, Alexander Lysko, Ekaterina Vasilevskaya, Allan V. Kalueff, Liliya Fedulova, Aleksei Umriukhin, Klaus-Peter Lesch, Daniel C. Anthony, Tatyana StrekalovaAbstractAimsThe high sugar and lipid content of the Western diet (WD) is associated with metabolic dysfunction, non-alcoholic steatohepatitis, and it is an established risk factor for neuropsychiatric disorders. Our previous studies reported negative effects of the WD on rodent emotionality, impulsivity, and sociabil...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 13 December 2019Source: The Journal of Supercritical FluidsAuthor(s): Wei Qiang, Ling Zhao, Tao Liu, Zhen Liu, Xiulu Gao, Dongdong HuAbstractA new method is presented to improve the efficiency of the supercritical CO2 foaming process and optimize the foam structure after evaluating the effect of alcohols as co-blowing agents on supercritical CO2 foaming polystyrene (PS). The simulations revealed that the solubility parameter of the blowing agents and the diffusion coefficient of CO2 for PS increased with the growth of chain length of alcohol. The addition of decanol decelerated the desorp...
Source: The Journal of Supercritical Fluids - Category: Chemistry Source Type: research
Publication date: 1 March 2020Source: Sensors and Actuators B: Chemical, Volume 306Author(s): Wen-Kui Li, Yu-Zhu Ding, Jun-Tao Feng, Zhi-Qing MaAbstractA dual-ligands of terephthalic acid (TPA) and methylimidazole (MIM) co-coordinated Eu(III) complex was designed and constructed based on a simple, low-cost, feasible and effective one-pot hydrothermal strategy. The luminescent inorganic-organic complex integrated the advantages of functional ligands and photoelectric unit of Eu(III), exhibited superior physical-chemical properties. Noteworthily, its fluorescence emission can be selectively and sensitively tuned by acetaldeh...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
Publication date: 1 March 2020Source: Inorganica Chimica Acta, Volume 502Author(s): Prasenjit Sarkar, Samir Ghorai, Ganesh Chandra Paul, Mahmuda Khannam, Surajit Barman, Chandan MukherjeeAbstractNoninnocent ligand H3LCH2OH reacted with NiCl2·6H2O under aerial atmosphere and provided corresponding complexes 1 {[NiII(HLCH2OH)2]0} and 1a {[NiII(LCHO)2]0} in the presence of Et3N and NaOH, respectively. Ligand H4LCH2NH2 provided complex 2 {[NiII(HL3]0} in the presence of NiCl2·6H2O and Et3N under air. All the complexes were characterized by various spectroscopic and spectrometric techniques, which included FT-IR, ...
Source: Inorganica Chimica Acta - Category: Chemistry Source Type: research
Authors: Abbott KL, Flannery PC, Gill KS, Boothe DM, Dhanasekaran M, Mani S, Pondugula SR Abstract Adverse pharmacokinetic interactions between illicit substances and clinical drugs are of a significant health concern. Illicit substances are taken by healthy individuals as well as by patients with medical conditions such as mental illnesses, acquired immunodeficiency syndrome, diabetes mellitus and cancer. Many individuals that use illicit substances simultaneously take clinical drugs meant for targeted treatment. This concomitant usage can lead to life-threatening pharmacokinetic interactions between illicit subst...
Source: Drug Metabolism Reviews - Category: Drugs & Pharmacology Tags: Drug Metab Rev Source Type: research
PURPOSE: Pedestrian trauma due to motor vehicle crashes can be especially destructive to the pediatric population as the facial skeleton is immature and developing. Almost half of crashes resulting in pedestrian death involved alcohol consumption, and chil...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Conclusion/Importance: Findings draw attention to the importance of understanding levels of life satisfaction, sensation seeking, perceived harm, academic grades, and disciplinary problems as they pertain to contemporary patterns of PSU. Schools should consider a tailored and multi-tiered approach to addressing students' substance use. PMID: 31829078 [PubMed - as supplied by publisher]
Source: Substance Use and Misuse - Category: Addiction Tags: Subst Use Misuse Source Type: research
The Editorial Board of Women's Health Issues is pleased to announce that the Charles E. Gibbs Leadership Prize for the best paper published in Women's Health Issues in 2019 (Volume 29) has been awarded to Sarah C.M. Roberts, DrPH, an associate professor with Advancing New Standards in Reproductive Health (ANSIRH) at the University of California, San Francisco. Her manuscript, “State Policies Targeting Alcohol Use during Pregnancy and Alcohol Use among Pregnant Women 1985–2016: Evidence from the Behavioral Risk Factor Surveillance System,” was co-authored by Amy A.
Source: Womens Health Issues - Category: Primary Care Tags: Editor's Note Source Type: research
Authors: Le P, Chaitoff A, Rothberg MB, McCullough A, Alkhouri N Abstract BackgroundWe aimed to estimate population-based trends in prevalence of coexisting type 2 diabetes (T2D) and suspected non-alcoholic fatty liver disease (NAFLD) and pioglitazone use among US adults.Research design and methodsWe conducted a cross-sectional analysis of the National Health and Nutrition Examination Survey from 2003-2016. We included people aged ≥18 years who had HbA1C>6.4%, fasting plasma glucose>125 mg/dL, or were told they had diabetes by a doctor. Suspected NAFLD was defined using hepatic steatosis index of>36. Pr...
Source: Expert Opinion on Investigational Drugs - Category: Drugs & Pharmacology Tags: Expert Opin Investig Drugs Source Type: research
Overexpression of AKR1B10 correlated with tumorigenesis of many human malignancies; however, the prognostic value of AKR1B10 expression in patients with hepatocellular carcinoma (HCC) still remains controversial. In this analysis, AKR1B10 expression in HCC tumors were evaluated in GEO, TCGA and Oncomine databases, and a survival analysis of AKR1B10 based on TCGA profile was performed. We found that AKR1B10 was significantly overexpressed in tumors compared with nontumors in 7 GEO series (GSE14520, GSE25097, GSE33006, GSE45436, GSE55092, GSE60502, GSE77314) and TCGA profile (all P
Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Paper Source Type: research
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