Deep brain stimulation in obsessive-compulsive disorder - case report of two patients.

Deep brain stimulation in obsessive-compulsive disorder - case report of two patients. Psychiatr Pol. 2019 Aug 31;53(4):807-824 Authors: Beszłej JA, Siwicki D, Fila-Witecka K, Wieczorek T, Piotrowski P, Weiser A, Tabakow P, Rymaszewska J Abstract Obsessive-compulsive disorder (OCD) occurs in 2-3% of the general population. Due to its chronicity and high resistance to standard treatment, alternative clinical management based on neuroscientific findings has been sought. Deep brain stimulation (DBS) is a modern and dynamic approach in the treatment of OCD giving hope to patients who are resistant to current pharmacotherapy and psychotherapy based treatments. This paper presents two cases of patients diagnosed with refractory OCD who received DBS therapy with concurrent pharmacotherapy and cognitive behavioral psychotherapy (CBT). Both patients underwent a neurosurgical procedure to implant electrodes into the anterior limb of the internal capsule (ALIC) and nucleus accumbens (NAc). Before and after the start of neurostimulation, patients underwent a clinical evaluation which consisted of a psychiatric examination and psychometric measurements (Y-BOCS, HAMA, HDRS, GAF, SOFAS). During the follow-up period, a blind attempt to switch off the neurostimulation was made. During the 6-month follow-up period, a significant reduction in the obsessive-compulsive, depressive and anxiety symptoms was achieved as well as an improvement in global patient functioning. The ...
Source: Psychiatria Polska - Category: Psychiatry Tags: Psychiatr Pol Source Type: research

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Source: The Journal of Nervous and Mental Disease - Category: Psychiatry Tags: Original Articles Source Type: research
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Source: Journal of Clinical Psychiatry - Category: Psychiatry Tags: J Clin Psychiatry Source Type: research
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Source: Nordic Journal of Psychiatry - Category: Psychiatry Tags: Nord J Psychiatry Source Type: research
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Source: Nordic Journal of Psychiatry - Category: Psychiatry Tags: Nord J Psychiatry Source Type: research
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Source: Psychological Medicine - Category: Psychiatry Authors: Tags: Psychol Med Source Type: research
Deep brain stimulation (DBS) may lead to improvements in patients with treatment-resistant obsessive-compulsive disorder (OCD), reports astudy published today in AJP in Advance.In the open study of 70 OCD patients who received DBS of a region called the ventral anterior limb of the internal capsule (vALIC), Damiaan Denys, M.D., Ph.D., of the University of Amsterdam and colleagues found that during the first year following the procedure, patients on average experienced significant improvements in symptoms of OCD, anxiety, and depression. The findings support the results of a DBS trial involving 16 OCD patients reported in 2...
Source: Psychiatr News - Category: Psychiatry Tags: ajp in advance anxiety Damiann Denys deep brain stimulation depression HAM-A HAM-D obsessive-compulsive disorder Y-BOCS Source Type: research
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Source: Psychological Medicine - Category: Psychiatry Authors: Tags: Psychol Med Source Type: research
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