Evaluation of drug utilization in cardiovascular disease at a teaching and referral hospital in Northern Telangana

CONCLUSION: Polypharmacy and least use of generic name were observed in the study which may affect the rationality. The use of antiplatelets, statins, and angiotensin-converting enzyme-inhibitors was appropriate, but furosemide overuse is of major concern. Therefore, appropriate prescription writing improvises treatment compliance in the patients, which results in rationality.
Source: Indian Journal of Pharmacology - Category: Drugs & Pharmacology Authors: Source Type: research

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Conclusions and Implications: Simvastatin, probably acting through the Notch1 pathway, decreases inflammation, improving cardiac function in chronically T. cruzi-infected mice. PMID: 32393497 [PubMed - as supplied by publisher]
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research
Conclusion: Patients with HCM may have higher plasma D-dimer levels than subjects without HCM. D-dimer levels in patients with HCM are influenced by age, sex, atrial fibrillation, statin therapy and diastolic blood pressure. PMID: 32057272 [PubMed - as supplied by publisher]
Source: Future Medicine: Biomarkers in Medicine - Category: Internal Medicine Tags: Biomark Med Source Type: research
Authors: Langsjoen PH, Langsjoen JO, Langsjoen AM, Rosenfeldt F Abstract CONTEXT: Heart failure (HF) is rapidly increasing in incidence and is often present in patients receiving long-term statin therapy. OBJECTIVE: To test whether or not patients with HF on long-term statin therapy respond to discontinuation of statin therapy and initiation of coenzyme Q10 (CoQ10) supplementation. DESIGN: We prospectively identified patients receiving long-term statin therapy in whom HF developed in the absence of any identifiable cause. Treatment consisted of simultaneous statin therapy discontinuation and CoQ10 supplemen...
Source: The Permanente journal - Category: General Medicine Tags: Perm J Source Type: research
Conclusion Activation of the Nrf2-dependent antioxidant system plays an important role in cell defense against oxidative stress damage, whereas the insufficiency of the Nrf2 system is associated with multiple aspects of the genesis and progression of metabolic diseases, posing a great risk to the cardiovascular system (Figure 1). The systemic increase of Nrf2 activity by several activators may be beneficial in the treatment of metabolic diseases. In addition, selective upregulation of Nrf2 genes may represent a potential therapy in obesity, diabetes and atherosclerosis. Looking to the future, experimental research that el...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Duchenne muscular dystrophy (DMD), is the most common and severe neuromuscular disease affecting skeletal and cardiac muscle. Here, we showed that simvastatin both reversed pre ‐existing cardiac dysfunction and prevented its development during long‐term treatment of dystrophic mice. Simvastatin also prevented the progression of dystrophic cardiac fibrosis. Together, these findings indicate that simvastatin markedly improves cardiac health and function in dystrophic mic e, and therefore may provide a novel approach for treating cardiomyopathy in DMD patients. AbstractDuchenne muscular dystrophy (DMD), caused by absence ...
Source: Physiological Reports - Category: Physiology Authors: Tags: Original Research Source Type: research
This article is protected by copyright. All rights reserved. PMID: 30869158 [PubMed - as supplied by publisher]
Source: The Journal of Physiology - Category: Physiology Authors: Tags: J Physiol Source Type: research
This study was a subanalysis of our previous report of the result that the serial 123I-MIBG scintigraphic studies were the most useful prognostic indicator in patients with heart failure. Patients with heart failure [left ventricular ejection fraction (LVEF)
Source: Nuclear Medicine Communications - Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research
Do you have the feeling that genomics is all around this year and you cannot escape DNAs, SNPs, chromosomes and double spirals wherever you look? Do you suspect that even Billy Mack is considering a change to “Genes are all around you” in everyone’s favorite holiday movie, Love Actually? Well, that won’t be a surprise as Christmas and genetics have more in common than you think – and scientists are even working on figuring out Santa’s genetic make-up. Gene-edited Christmas trees and Santa’s DNA If it’s all in our genes, the explanation for the Grinch hating the holidays or Sa...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Genomics Patients christmas Christmas tree december dinner DNA dna testing food future Gene genes genetics holiday holidays Innovation nutrigenomics pharmacogenomics Santa technology Source Type: blogs
Individuals share about 99.97 percent of their DNA and only the remaining 0.03 percent is responsible for the differences in skin, hair or eye color, height, shoe size or sunspots. Scientists discovered somewhat recently that our bodies also metabolize drugs differently so it would make sense to prescribe medications based on the knowledge hidden in our DNA. In some cases, physicians already do that. Here’s what you need to know about pharmacogenomics and the future of prescription drugs. It’s all in your genes Why do some people eat creamy French cakes all the time, only do sports when they have to run after t...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Future of Pharma Genomics Medical Professionals Patients Researchers DNA dna testing drugs genetics Health Healthcare Innovation medication pharmacogenetics pharmacogenomics precision health precision medicine technology Source Type: blogs
ConclusionsMyocardial glucose utilization was influenced by substrates and medications, including statins and DPP4i. MRGlu could discriminate between viable and non-viable myocardium, and MRGlu in transmural match and reverse mismatch may be prognostic predictors of cardiovascular death in patients with ischemic cardiomyopathy.
Source: Journal of Nuclear Cardiology - Category: Nuclear Medicine Source Type: research
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