In vivo resuscitation, perfusion, and transplantation of a porcine cardiac allograft donated after circulatory death

ConclusionThis animal study demonstrates the feasibility of using this novel technique for resuscitation and precardiectomy evaluation of donated after circulatory death hearts. For those donor hearts without adequate function, an LVAD can be safely implanted as a “bail‐out” option. The limitations of this technique are the patient population to which it can be applied (only those patients eligible and consented for LVAD).
Source: Journal of Cardiac Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: ORIGINAL ARTICLE Source Type: research

Related Links:

Cardiac Allograft Vasculopathy (CAV) is a major cause of chronic cardiac allograft failure. Invasive coronary angiography (ICA) and intravascular ultrasound (IVUS) are the current diagnostic methods. Myocardial perfusion MRI has become a promising non-invasive method to evaluate myocardial ischemia, but has not been thoroughly validated in CAV. Our objective was to assess the repeatability of myocardial rest-perfusion MRI in healthy volunteers and its feasibility in detecting CAV in transplant patients (Tx).
Source: Clinical Imaging - Category: Radiology Authors: Tags: Cardiothoracic Imaging Source Type: research
Authors: Chew HC, Macdonald PS, Dhital KK Abstract Recent advancement in organ perfusion technology has led to increase clinical transplantation of marginal donor organs and allow for distant procurement of cardiac allograft beyond the time limitation of cold static storage. Ex-situ heart perfusion also provides essential nutrients to maintain cell integrity, thereby reducing the risk of ischaemic injury for functional preservation and provides a platform to assess organ viability and feasibility, with the potential for pharmacotherapy to recover these hearts. Notably, the use of NMP has led to the first distant pr...
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
Publication date: Available online 24 April 2019Source: Life SciencesAuthor(s): Hongwen Lan, Yunshu Su, Yakun Liu, Cheng Deng, Jing Wang, Taiqiang Chen, Kouevidjin Ekue Dodzi Jules, Jackson Ferdinand Masau, Huiling Li, Xiang WeiAbstractAimsThe shortage of donor hearts could be alleviated with the use of the allografts from donation after circulatory death (DCD). Here, we evaluated the protective effect of melatonin on myocardial ischemia/reperfusion (MI/R) injury in a DCD heart model after ex vivo perfusion.Main methodsDonor hearts were harvested from DCD model rats pre-treated with or without melatonin and subjected to 30...
Source: Life Sciences - Category: Biology Source Type: research
Conclusion As a critical regulator of inflammation and cell survival, the NFκB pathway is a promising target for diagnosing and treating kidney diseases. For modulation of the NFκB pathway in the clinic, a number of molecules can effectively inhibit NFκB signaling by targeting the receptors, associated adaptors, IKKs, IκBs and transcriptional regulators (144). There is further clinical evidence on small-molecule inhibitors of IKKα and NIK from recent trials on anti-cancer therapies (145). These clinical trials showed that the cancer-selective pharmacodynamic response of DTP3, the co-inhibitor...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
The risk of post-transplant lymphoproliferative disorder (PTLD), a B-cell malignancy caused by Epstein-Barr virus (EBV), is highest when latent virus is transmitted from B-cells within the allograft to a na ïve recipient. Ex-vivo lung perfusion (EVLP) is a potential platform to modify grafts before transplantation. We hypothesized that EVLP-mediated delivery of Rituximab (RTX), an antibody targeting CD20+ B-cells, may safely clear latent EBV from donor lungs and attenuate viral transmission.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 110 Source Type: research
We present our protocol for perfusion of porcine lungs with human stem cells using our ex-vivo machine.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 452 Source Type: research
The lack of hearts available for transplant remains a major concern. Recent strategies including ex-vivo technology and DCD organs have been utilized to expand donor pool.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 431 Source Type: research
Efforts to increase the number of viable donors, such as ex vivo lung perfusion and donation after circulatory death, are likely to significantly alter allograft ischemic time distributions. As such, understanding the impact allograft ischemia has on short and long-term outcomes will be key in determining best practices going forward.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 815 Source Type: research
In the diagnosis of chronic lung allograft dysfunction (CLAD) after living-donor lobar lung transplantation (LDLLT), lung ventilation scintigraphy using 133Xe has been shown to be useful. However, the supply of 133Xe has been discontinued worldwide in 2016 and a new diagnostic tool is required for CLAD after LDLLT. Generally, because CLAD has been shown to develop predominantly on one side after bilateral LDLLT, lung perfusion scintigraphy (LPS) could show a perfusion shift to the unilateral healthy lung (Figure 1A).
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 1030 Source Type: research
Abstract Heart transplantation remains the definitive management for end-stage heart failure refractory to medical therapy. While heart transplantation cases are increasing annually worldwide, there remains a deficiency in organ availability with significant patient mortality while on the waiting list. Attempts have therefore been made to expand the donor pool and improve access to available organs by recruiting donors who may not satisfy the standard criteria for organ donation because of donor pathology, anticipated organ ischemic time, or donation after circulatory death. "Ex vivo" heart perfusion (EV...
Source: Anesthesia and Analgesia - Category: Anesthesiology Authors: Tags: Anesth Analg Source Type: research
More News: Bone Graft | Cardiology | Cardiovascular & Thoracic Surgery | Grants | Heart | Heart Transplant | Perfusion | Study | Transplant Surgery | Transplants