GSE140913 MicroRNA expression profiles in plexiform neurofibromas and malignant peripheral nerve sheath tumors derived from the same neurofibromatosis type 1 patient

Contributors : Azadeh Amirnasr ; Robert M Verdijk ; Patricia F van Kuijk ; Pinar Kartal ; Anne L Vriends ; Pim J French ; Martin E van Royen ; Walter Taal ; Stefan Sleijfer ; Erik A WiemerSeries Type : Expression profiling by RT-PCROrganism : Homo sapiensMalignant peripheral nerve sheath tumors (MPNST) are aggressive cancers that occur spontaneously (sporadic MPNST) or from pre-existing, benign plexiform neurofibromas in neurofibromatosis type 1 (NF1) patients. MPNSTs metastasize easily, are resistant to therapeutic intervention and are frequently fatal. The molecular changes underlying the transition to malignancy in the NF1 setting are incompletely understood. Here we investigate the involvement of microRNAs in this process. Using an RT-PCR platform microRNA expression profiles were determined from a unique series of archival paired samples of plexiform neurofibroma and MPNST. At least 90 differentially expressed microRNAs (p
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by RT-PCR Homo sapiens Source Type: research