Computed tomography-measured body composition: correlation with postoperative morbidity and mortality in patients with gastroesophageal cancer

Conclusion: Our data suggest that lean body mass can be a relevant prognostic factor in patients with gastric or esophageal cancer, and that CT measurements should be included in the routine preoperative evaluation, because it may provide information that aids nutritional and clinical care for these patients.Resumo Objetivo: Investigar se medidas antropom étricas e tomografia computadorizada (TC) da composição corporal podem predizer morbimortalidade pós-operatória em pacientes com câncer gástrico e/ou esofágico. Materiais e Métodos: Estudo retrospectivo que revisou prontuários médicos e TCs abdominais de pacientes com câncer gástrico e /ou esofágico que foram operados em 2015 em um centro de referência oncológico. As TCs realizadas durante a avaliação pré- operatória de rotina foram avaliadas retrospectivamente para medir a área de massa magra ao nível de L3 e gordura visceral e subcutânea. Resultados: Setenta pacientes foram incluídos no estudo. A média de idade foi 59,9 anos (faixa de 33-82 anos), e 47 desses pacientes (67,1%) eram homens. O seguimento pós-operatório médio foi 14,9 meses. Não houve associação significativa entre morbidade ou mortalidade pós-operatória e sexo, idade, tumor primário, co morbidades, tabagismo, índice de ma...
Source: Radiologia Brasileira - Category: Radiology Source Type: research

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Conclusions: Nutrition counseling was rarely documented in a large sample of electronic medical record (EMR) data from pediatric wellness visits in South Carolina-a state heavily burdened by childhood obesity. Children's BMIs were infrequently recorded, which may be a barrier to tracking BMI over time. Sociodemographic and geographic differences in nutrition counseling may exacerbate disparities in childhood obesity. PMID: 32960095 [PubMed - as supplied by publisher]
Source: Childhood Obesity - Category: Eating Disorders & Weight Management Tags: Child Obes Source Type: research
Publication date: Available online 22 September 2020Source: Academic RadiologyAuthor(s): Waqas T. Qureshi, Rohit Malhotra, Eric J. Schmidlin, Mohamed Ahmed, Amartya Kundu, Abdul Moiz Hafiz, Jennifer Walker, Nikolaos Kakouros
Source: Academic Radiology - Category: Radiology Source Type: research
Publication date: Available online 21 September 2020Source: Academic RadiologyAuthor(s): Alireza Zali, Mohammad-Reza Sohrabi, Ali Mahdavi, Nastaran Khalili, Morteza Sanei Taheri, Ali Maher, Mohammadmehdi Sadoughi, Afshin Zarghi, Seyed Ali Ziai, Abbas Arjmand Shabestari, Mehrdad Bakhshayeshkaram, Hamidreza Haghighatkhah, Babak Salevatipour, Alireza Abrishami, Masoomeh Raoufi, Pooneh Dehghan, Arash Khameneh Bagheri, Reza Jalili Khoshnoud, Khatereh Hanani
Source: Academic Radiology - Category: Radiology Source Type: research
Publication date: December 2020Source: Social Science &Medicine, Volume 266Author(s): Trang Thu Do, Andrea Whittaker
Source: Social Science and Medicine - Category: Psychiatry & Psychology Source Type: research
In this study, β2∗ nAChR-containing receptors and lynx1 were identified using pull down studies from the mouse brain (Nissen et al., 2018), while ws-lynx1, SLURP-1 and SLURP-2 has been successfully mixed with human brain tissue to pull down multiple nAChR subtypes (Lyukmanova et al., 2016a,b; Thomsen et al., 2016). To support the in vivo interaction studies, a lynx1KO phenotype was ameliorated by crossing these mice into mutant mice null for α7 and β2 nAChR genes (Miwa et al., 2006). These in vivo studies provide an important biological context for the interactions observed within in vitro systems. ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Conclusions This review describes how leukocyte-heparanase can be a double-edged sword in tumor progression; it can enhance tumor immune surveillance and tumor cell clearance, but also promote tumor survival and growth. We also discuss the potential of using heparanase in leukocyte therapies against tumors, and the effects of heparanase inhibitors on tumor progression and immunity. We are just beginning to understand the influence of heparanase on a pro/anti-tumor immune response, and there are still many questions to answer. How do the pro/anti-tumorigenic effects of heparanase differ across different cancer types? Does...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Discussion Suppressor of cytokine signaling 1 is an essential molecule for maintaining immune homeostasis and subverting inflammation. Disorders arising from excess inflammation or SOCS1 deficiency can be potentially treated with SOCS1 mimetics (Ahmed et al., 2015). While SOCS1 has promising potential in many disorders, it should be noted that new targets and actions of SOCS1 are still being discovered and not all the effects of this protein are beneficial in autoimmune diseases and cancer. For instance, SOCS1 degrades IRS1 and IRS2, required for insulin signaling, via the SOCS Box domain, thus, limiting its potential in ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
This article highlights dietary factors as major contributors to this rising trend of cancer incidence in Kenya at the backdrop of an evolving diet. Literature search revealed that diet plays a major role in the etiology of various cancers with highest incidence rates in various categories of people in Kenya. Other than among children (≤15 years) and HIV/AIDs patients, diet-related cancers such as esophageal, colorectal, stomach, prostate and breast appear to predominate among Kenyans in various categories, i.e., young people (15 ≤ 30 years), adults (31 ≤ 65 years), and older people (&g...
Source: Nutrition and Cancer - Category: Cancer & Oncology Authors: Tags: Nutr Cancer Source Type: research
Abstract: We utilized computerized record-linkage methods to link HIV and cancer databases with limited unique identifiers in Pune, India, to determine feasibility of linkage and obtain preliminary estimates of cancer risk in persons living with HIV (PLHIV) as compared with the general population. Records of 32,575 PLHIV were linked to 31,754 Pune Cancer Registry records (1996–2008) using a probabilistic-matching algorithm. Cancer risk was estimated by calculating standardized incidence ratios (SIRs) in the early (4–27 months after HIV registration), late (28–60 months), and overall (4–60 months) i...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
All normal cells grow and divide. But cancer cells grow without limit. They divide without stopping. They change and they spread, invading healthy tissues. And all too often, they're lethal. On World Cancer Day, we have a very simple message: to overpower a disease that thrives on dividing, we must unite around research. Cancer knows no age, gender or race. It has no boundaries. As cancer's toll grows around the world, it is becoming just as much a threat to global health and development as infectious diseases. According to the World Health Organization more people die from cancer than from AIDS, malaria and tuberculosis ...
Source: Science - The Huffington Post - Category: Science Source Type: news
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