Rare polio cases caused by vaccine outnumbering wild virus infections, report says
More children in Africa being paralyzed by viruses originating in polio vaccines than in the wild, according to a new report.
AbstractNearly 20 years after the year 2000 target for global wild poliovirus (WPV) eradication, live polioviruses continue to circulate with all three serotypes posing challenges for the polio endgame. We updated a global differential equation ‐based poliovirus transmission and stochastic risk model to include programmatic and epidemiological experience through January 2020. We used the model to explore the likely dynamics of poliovirus transmission for 2019–2023, which coincides with a new Global Polio Eradication Initiative Strategi c Plan. The model stratifies the global population into 72 blocks, each containi...
[ANGOP] Luanda -At least five million children were vaccinated in the country in 2019 to fight poliomyelitis during the campaigns promoted by the Ministry of Health, said last Friday in Luanda, the minister S ílvia Lutucuta.
Condition: Polio Interventions: Biological: IMOVAX Inactivated Poliomyelitis Vaccine (IPV); Biological: dmLT (adjuvant); Biological: Bivalent oral polio vaccine (bOPV) Sponsor: PATH Not yet recruiting
ConclusionsReceiving the birth dose is positively associated with up-to-date status later in childhood, highlighting the importance of starting vaccination early. The association is insensitive to confounding by factors observed in National Immunization Survey-Child, but investigation of unobserved factors such as vaccine hesitancy could provide critical information to guide intervention strategy.
Abstract Current inactivated polio vaccine (IPV) products are sensitive to both freezing and elevated temperatures and therefore must be shipped and stored between 2 °C and 8 °C, a requirement that imposes financial and logistical challenges for global distribution. As such, there is a critical need for a robust, thermally stable IPV to support global polio eradication and post-eradication immunization needs. Here, we present the development of air-dried thin films for temperature stabilization of IPV using the biomaterial silk fibroin. Thin-film product compositions were optimized for physical p...
We present an alternative, societal framework for economic evaluations that encompasses a broader set of socioeconomic benefits in addition to health benefits. Quantifying a more comprehensive taxonomy of PCV’s benefits will help to address potential undervaluation and may be sufficient not only to justify recommendation and reimbursement but also to stimulate efforts and investment toward closing coverage gaps.
Abstract Insulin quality and efficacy determine glycemic control, which determines quality of life for people with diabetes. Insulin efficacy is reduced by heat exposure, especially in tropical climates, remote areas, and with improper handling. Insulin doses can be adjusted based on blood glucose monitoring, which may compensate for lack of viability. However, a measured response may be difficult with other biopharmaceuticals. Thermochromic vial monitor technology developed for oral polio vaccines (vaccine vial monitors) is an inexpensive, easily available, visible modality which can be used for insulin and other...
Condition: Poliomyelitis Interventions: Biological: sIPV batch 1; Biological: sIPV batch 2; Biological: sIPV batch 3 Sponsor: Chinese Academy of Medical Sciences Completed