Gut microbes alter characteristics of norovirus infection

(Washington University School of Medicine) The highly contagious norovirus causes diarrhea and vomiting and is notorious for spreading rapidly through densely populated spaces, such as cruise ships, nursing homes, schools and day care centers. There are no treatments for this intestinal virus. A new study led by scientists at Washington University School of Medicine in St. Louis has shown that gut microbes can tamp down or boost the severity of norovirus infection based on where along the intestine the virus takes hold.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news

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Publication date: February 2020Source: The Lancet Global Health, Volume 8, Issue 2Author(s): Kirkby D Tickell, Rumana Sharmin, Emily L Deichsel, Laura M Lamberti, Judd L Walson, A S G Faruque, Patricia B Pavlinac, Karen L Kotloff, Mohammod J ChistiSummaryBackgroundHost vulnerabilities associated with acute malnutrition could facilitate the ability of specific enteric pathogens to cause diarrhoea and associated mortality. Using data from the Global Enteric Multicenter Study, we assessed whether acute malnutrition modifies the association between common enteric pathogens and moderate-to-severe diarrhoea, and whether associat...
Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research
Contributor : Byung-joo ParkSeries Type : Expression profiling by high throughput sequencingOrganism : Sus scrofaPurpose: We investigated the host immune response and the virus evasion mechanism in gnotobiotic pig infected with HuNoV by mRNA sequencing.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Sus scrofa Source Type: research
Human noroviruses (HuNoVs) cause sporadic and epidemic outbreaks of gastroenteritis in all age groups worldwide. We previously reported that stem cell-derived human intestinal enteroid (HIE) cultures support replication of multiple HuNoV strains and that some strains (e.g., GII.3) replicate only in the presence of bile. Heat- and trypsin-treatment of bile...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Biological Sciences Source Type: research
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Source: - Health - Category: Consumer Health News Source Type: news
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Source: Healthcare News - Category: Pharmaceuticals Authors: Source Type: news
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Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
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Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news
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Source: Health News: - Category: Consumer Health News Source Type: news
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Source: the Mail online | Health - Category: Consumer Health News Source Type: news
K. Charoenkul et al.
Source: Emerging Infectious Diseases Journal - Category: Infectious Diseases Source Type: research
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