Review of Clinical Studies Targeting Inflammatory Pathways for Individuals With Autism
Immune dysfunction and abnormal immune response may be associated with certain mechanisms underlying autism spectrum disorder (ASD). The early evidence for this link was based on the increased incidence of ASD in children with a history of maternal infection during pregnancy. Observational studies show increased prevalence of immune-related disorders—ranging from atopy, food allergy, viral infections, asthma, primary immunodeficiency, to autoimmune disorders—in individuals with ASD and their families. Evidence of neuroglial activation and focal brain inflammation in individuals with ASD implies that the central nervous system immunity may also be atypical in some individuals with ASD. Also, both peripheral and central inflammatory responses are suggested to be associated with ASD-related behavioral symptoms. Atypical immune responses may be evident in specific ASD subgroups, such as those with significant gastrointestinal symptoms. The present review aimed to evaluate current literature of potential interventions that target inflammatory pathways for individuals with ASD and to summarize whether these interventions were associated with improvement in autism symptoms and adaptation. We found that the current literature on the efficacy of anti-inflammatory interventions in ASD is still limited and large-scale randomized controlled trials are needed to provide robust evidence. We concluded that the role of immune-mediated mechanisms in the emergence of ASD or related...
Publication date: April 2020Source: Research in Autism Spectrum Disorders, Volume 72Author(s): Daniel E. Lidstone, Faria Z. Miah, Brach Poston, Julie F. Beasley, Janet S. DufekAbstractBackgroundPostural control deficits are commonly reported in children with Autism Spectrum Disorder (ASD). However, identification of specific postural sway features that differentiate ASD from other neurodevelopmental disorders has not been examined. The current study employs a cross-syndrome approach by comparing postural sway area and direction-specific features of sway magnitude, sway velocity, and sway complexity between children with AS...
ConclusionsSelf-report studies provide individuals on the autism spectrum with a much-needed opportunity to express and share their attributes, strengths and interests with others, adding their voice to the literature. Further work is needed to explore the impact of such positive self-descriptions on an individual’s positive sense of self and self-confidence.
ConclusionsFurther research is warranted to reveal the potential use of CYP2C9 and SLC6A2 SNP expression as pharmacogenetic biomarkers to determine the most appropriate medication for individuals with autism and/or GI dysfunction.
Publication date: Available online 22 January 2020Source: Revista Española de Cardiología (English Edition)Author(s): Ernesto Valero, Jessika González-D’Gregorio, Nieves Carbonell, Mónica García-Simón, José Ferreres, Juan Sanchis
Publication date: Available online 23 January 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Cindy L.J. Weinstein, Nicholas Ryan, Xiaoli Zhang, Tulin Shekar, Davis Gates, Stephen J. Lane, Ioana Agache, Robert A. Nathan, SPIRO InvestigatorsAbstractBackgroundDue to historical safety concerns with use of long-acting beta agonists in asthma, step-down from inhaled corticosteroid/long-acting beta agonist (ICS/LABA) combination therapy to ICS monotherapy is recommended once asthma control is achieved.ObjectiveTo evaluate the benefit/risk question about whether asthma patients who achieve diseas...
Publication date: Available online 23 January 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Caitlin Carrigan, Joshua D. Milner, Jonathan J. Lyons, Peter Vadas
Publication date: Available online 22 January 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Nicola A. Hanania, Ratko Djukanovic, Liam G. Heaney, Ming Yang, Bongin Yoo, Ahmar Iqbal, Noelle M. Griffin, Bradley E. Chipps
ConclusionsThe clinical phenotype of asthma that persists from childhood to adulthood seems to be a distinct phenotype of adult asthma.
In this study, using volumetric-based methodology and structural covariance approach, we investigated structural covariance of subcortical brain volume in 40 young children with ASD (
CONCLUSIONS: Arabic-speaking women from Arab countries have higher risks of stillbirth compared with the French and English majority in Quebec. Strategies to reduce stillbirth risk among Arabic speakers should focus on improving identification of causes of death. PMID: 31968204 [PubMed - as supplied by publisher]