Maya gene variants related to the risk of type 2 diabetes in a family-based association study.

This study also included the family-based association test (FBAT) statistic U to assess the genetic associations with T2D, and the multivariate statistical and haplotype analyses. A positive association with TD2 risk was found for WFS1 rs6446482 (p=0.046, Z=1.994) under an additive model, and SIRT1 rs7896005 (p= 0.038, Z=2.073) under the dominant model. Multivariate model analysis, including T2D status, age, and body mass index (BMI), displayed significant covariance in PPARGC-1α rs8192678; SIRT1 rs7896005; TCF7L2 rs7903146 and rs122243326; UCP3 rs3781907; and HHEX rs1111875 with a P<0.05. This study revealed an association of SIRT1 and WFS1 with T2D risk. PMID: 31759989 [PubMed - as supplied by publisher]
Source: Gene - Category: Genetics & Stem Cells Authors: Tags: Gene Source Type: research