Comorbidity associated to < i > Ascaris suum < /i > infection during pulmonary fibrosis exacerbates chronic lung and liver inflammation and dysfunction but not affect the parasite cycle in mice

by Fabr ício Marcus Silva Oliveira, Pablo Hemanoel da Paixão Matias, Lucas Kraemer, Ana Clara Gazzinelli-Guimarães, Flaviane Vieira Santos, Chiara Cássia Oliveira Amorim, Denise Silva Nogueira, Camila Simões Freitas, Marcelo Vidigal Caliari, Daniella Castanheira Bartholomeu, Lilian Lacerda Bueno, Remo Castro Russo, Ricardo Toshio Fujiwara Ascariasis is considered the most neglected tropical disease, and is a major problem for the public health system. However, idiopathic pulmonary fibrosis (IPF) is a result of chronic extracellular deposition of matrix in the pulmonary parenchyma, and thickening of the alveolar septa, which reduces alveolar gas exchange. Considering the high rates of ascariasis and pulmonary fibrosis, we believe that these two diseases may co-exist and possibly lead to comorbidities. We therefore investigated the mechanisms involved in comorbidity ofAscaris suum (A.suum) infection, which could interfere with the progression of pulmonary fibrosis. In addition, we evaluated whether a previous lung fibrosis could interfere with the pulmonary cycle ofA.suum in mice. The most important findings related to comorbidity in whichA.suum infection exacerbated pulmonary and liver injury, inflammation and dysfunction, but did not promote excessive fibrosis in mice during the investigated comorbidity period. Interestingly, we found that pulmonary fibrosis did not alter the parasite cycle that transmigrated preferentially through preserved but not fibrotic areas of th...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research