Mast Cell Activation: When the Whole Is Greater than the Sum of Its Parts.

Mast Cell Activation: When the Whole Is Greater than the Sum of Its Parts.
Med Clin North Am. 2020 Jan;104(1):177-187
Authors: Khokhar D, Akin C
Abstract
Mast cell activation syndrome (MCAS) is a heterogeneous and rare disorder with episodic and severe activation of mast cells. Because symptoms of mast cell activation are nonspecific, it is important to base the diagnosis on best available clinical and scientific evidence, and not make it one of exclusion. MCAS, much like the mast cell itself, as a whole is greater than the sum of its proposed diagnostic criteria. When each component is considered in isolation, criteria can seem nonspecific, and thus, a broad constellation of symptoms can be attributed to MCAS when they may be due to other disease processes.
PMID: 31757235 [PubMed - in process]

Source: The Medical Clinics of North America - November 25, 2019 Category: General Medicine Authors: Khokhar D, Akin C Tags: Med Clin North Am Source Type: research