Clinical outcomes of patients with POLE mutated endometrioid endometrial cancer.

CONCLUSIONS: Patients with POLE EDM EEC have been shown to have a favorable prognosis. In this real-world cohort of patients, de novo metastatic disease and recurrences in initially uterine-confined cases were observed. Further research is warranted before incorporating the presence of POLE EDM into decision-making regarding adjuvant therapy.
PMID: 31757464 [PubMed - as supplied by publisher]

Source: Gynecologic Oncology - November 18, 2019 Category: Cancer & Oncology Authors: Stasenko M, Tunnage I, Ashley CW, Rubinstein MM, Latham AJ, Da Cruz Paula A, Mueller JJ, Leitao MM, Friedman CF, Makker V, Soslow RA, DeLair DF, Hyman DM, Zamarin D, Alektiar KM, Aghajanian CA, Abu-Rustum NR, Weigelt B, Cadoo KA Tags: Gynecol Oncol Source Type: research