The impact of serum protein binding on bacterial killing of minocycline

ConclusionAntimicrobial activity of minocycline was dramatically reduced in the presence of serum, which corroborated with our atypical serum protein binding findings. If validated, these results implied dose escalation might not the best approach to improve the clinical efficacy of minocycline for bacteremia. Future investigations will focus on the specificity and mechanism(s) of minocycline protein binding.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research