Monoamine oxidase-A activity is required for clonal tumorsphere formation by human breast tumor cells.

Conclusions: Our data suggests that MAO-A activity is required for tumorsphere formation and that its expression in breast tumor cells is associated with BTIC-related properties. The discovery that a selective MAO-A inhibitor targets tumorsphere-forming cells with potencies in the nanomolar range provides the first evidence of this agent's anticancer property. These data warrant further investigation of the link between MAO-A and BTIC.
PMID: 31754354 [PubMed - in process]

Source: Cellular and Molecular Biology Letters - November 24, 2019 Category: Biochemistry Authors: Gwynne WD, Shakeel MS, Wu J, Hallett RM, Girgis-Gabardo A, Dvorkin-Gheva A, Hassell JA Tags: Cell Mol Biol Lett Source Type: research