Salivary mir-27b expression in oral lichen planus patients: a series of cases and a narrative review of litterature.
Salivary mir-27b expression in oral lichen planus patients: a series of cases and a narrative review of litterature. Curr Top Med Chem. 2019 Nov 21;: Authors: Stasio DD, Mosca L, Lucchese A, Cave DD, Kawasaki H, Lombardi A, Porcelli M, Caraglia M Abstract BACKGROUND: microRNAs play a critical role in auto-immunity, cell proliferation, differentiation and cell death. miRNAs are present in all biological fluids, and their expression is essential in maintaining regular immune functions and preventing autoimmunity, whereas miRNA dysregulation may be associated with the pathogenesis of autoimmune and inflammatory diseases. Oral lichen planus (OLP) is an inflammatory disease mediated by cytotoxic T cells attack against epithelial cells. The present study aims to perform a specific microRNA expression profile through the analysis of saliva in this disease. METHODS: The study group was formed by five patients (mean age 62.8±1.98 years; 3 females/2 males) affected by oral lichen planus and control group by five healthy subjects (mean age 59.8 years±2.3; 3 females/ 2 males); using a low-density microarray analysis, we recorded a total of 98 differentially expressed miRNAs in the saliva of patients with oral lichen planus compared to the control group. The validation was performed for miR-27b with qRT-PCR in all saliva samples of oral lichen planus group. RESULTS: 89 miRNAs were up-regulated and nine down-regulated. In details, levels of miR...
Conclusion: PECAM-1 was found to be overexpressed in OLP; difference in PECAM-1 expression was noted between the reticular and erosive types. The VAMs could be exploited as a possible therapeutic target in OLP to modulate the disease process thereby reducing the dependency on corticosteroids.
CONCLUSIONS: This study on dry eye confirmed but also refuted many risk factors from smaller epidemiological studies, and discovered numerous new risk factors in multiple etiological categories. The finding that dry eye symptoms are particularly common in young adults is concerning, and warrants further study. PMID: 32376389 [PubMed - as supplied by publisher]
Authors: Chaitanya NC, Reshmapriyanka D, Pallavi K, Ameer S, Appala A, Chowdhary A, Prabhath T, Ratna MP, Sowmya BS, Vaishnavi C, Bontala P Abstract BACKGROUND: Oral lichen planus (OLP) is a T cell-mediated chronic autoimmune disorder directed against antigens secreted by the basal cell layer, with an incidence of 0.02-0.22% in Indian population and showing female predilection. Stress is considered one of the etiological factors in the causation, progression, and recurrence of this disease. OBJECTIVES: To evaluate the levels of serum cortisol, anxiety, and depression in patients with symptomatic OLP and to corr...
This study for the first time compares the expression of the aquaporin-3 (AQP3) gene in oral tissues of a group of OLP patients and a control group. In this study, 30 OLP patients and 30 healthy individuals were selected. The expression of AQP3 gene was measured using Real-Time PCR method. The expression of the gene in the OLP patients was more than the control group. It could be argued that decreased salivation increases the level of expression of the AQP3 gene in an effort to compensate for this deficiency and prevent the onset of xerostomia (compensatory up-regulation). PMID: 32289285 [PubMed - as supplied by publisher]
We report three patients who developed lichen sclerosus et atrophicus superimposed on skin involved by scleredema adultorum of Buschke. Although the association of lichen sclerosus et atrophicus with scleredema adultorum of Buschke could be coincidental, both diseases could be considered part of the spectrum of sclerodermoid disorders with common underlying pathogenetic mechanisms; which could explain the sequential or simultaneous occurrence of both lesions in our patients.
ConclusionsOral zinc therapy was found to be an adjunct in reducing burning sensation and lesion size in symptomatic OLP.
ConclusionsLeukocyte cell types and IL-17+ cells are important in this chronic disease process. This investigation adds to the scant body of literature on T-helper cell type 17 (Th17)/IL-17 involvement in canine idiopathic inflammatory and/or autoimmune diseases. As such, CCUS may represent a nonmouse model for other spontaneously occurring inflammatory diseases in canines and humans.
Many factors have been studied in order to identify the causes of oral lichen planus (OLP), such as use of drugs, autoimmune diseases, diabetes, and hepatitis C virus infection. Some researchers have been trying to find a connection between psychological states and OLP. The authors report a case of a 36-year-old female patient who went to the stomatology care service complaining of a "white ball on the tongue," which was causing her some discomfort over a year. During anamnesis, the patient reported taking lithium and bupropion (treating depression and anxiety, respectively).
This study aimed to compare the efficacy of a combination of oral zinc acetate 50 mg tablets and the 0.1% triamcinolone acetonide Orabase with Orabase alone in the healing process of symptomatic oral lichen planus (OLP).
In conclusion, elevated miR-29b interacts with IFN-γ via a regulatory feedback loop and induces global DNA hypomethylation in CD4+ T cells, which consequently modulates Type 1 T helper immune response, thus contributing to the immune dysregulation of OLP. PMID: 31739067 [PubMed - as supplied by publisher]