Right ventricular function correlates of right atrial strain in pulmonary hypertension: a combined cardiac magnetic resonance and conductance catheter study.

Right ventricular function correlates of right atrial strain in pulmonary hypertension: a combined cardiac magnetic resonance and conductance catheter study. Am J Physiol Heart Circ Physiol. 2019 Nov 22;: Authors: Tello K, Dalmer A, Vanderpool RR, Ghofrani HA, Naeije R, Roller F, Seeger W, Wiegand M, Gall H, Richter MJ Abstract The functional relevance of right atrial (RA) function in pulmonary hypertension (PH) remains incompletely understood. The purpose of this study was to explore the correlation of cardiac magnetic resonance (CMR) feature tracking-derived RA phasic function with invasively measured pressure-volume (PV) loop-derived right ventricular (RV) end-diastolic elastance (Eed) and RV-arterial coupling [end-systolic/arterial elastance (Ea/Ees)]. In 54 patients with severe PH, CMR was performed within 24 hours of diagnostic right heart catheterization and PV measurements. RA phasic function was assessed by CMR imaging of RA reservoir, passive, and active strain. The association of RA phasic function with indices of RV function was evaluated by Spearman's rank correlation and linear regression analyses. Median [interquartile range] RA reservoir, passive, and active strain were 19.5% [11.0-24.5], 7.0% [4.0-12.0], and 13.0% [7.0-18.5], respectively. Ees/Ea was 0.73 [0.48-1.08] and Eed was 0.14 mm Hg/ml [0.05-0.22]. RV diastolic impairment [RV end-diastolic pressure (EDP) and Eed] was correlated with RA phasic function, but Ea ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - Category: Physiology Authors: Tags: Am J Physiol Heart Circ Physiol Source Type: research