Industry updates from the field of stem cell research and regenerative medicine in September 2019.
Industry updates from the field of stem cell research and regenerative medicine in September 2019. Regen Med. 2019 Nov 22;: Authors: Ilic D, Liovic M, Noli L Abstract Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from nonacademic institutions in September 2019. PMID: 31755357 [PubMed - as supplied by publisher]
Conditions: CD38 Positive; Plasma Cell Myeloma Interventions: Biological: Astatine At 211 Anti-CD38 Monoclonal Antibody OKT10-B10; Drug: Melphalan; Procedure: Peripheral Blood Stem Cell Transplantation Sponsors: Fred Hutchinson Cancer Research Center; National Cancer Institute (NCI); National Institutes of Health (NIH) Not yet recruiting
Authors: Barastegui D PMID: 32643477 [PubMed - in process]
We examined the gross morphological changes in these lungs, the density and function of epithelial progenitor populations and the epithelial gene expression profile. Bronchioles became smaller in their cross-sectional area and diameter. We found that bronchiolar cell density remained stable with aging, but inferred rates of progenitor cell self-renewal and differentiation were reduced, indicative of an overall slowdown in cellular turnover. Alveolar Type II progenitor cell density and self-renewal were maintained per unit tissue area with aging, but rates of inferred differentiation into Type I cells, and indeed ove...
Publication date: Available online 8 July 2020Source: Stem Cell ResearchAuthor(s): Tong Yi, Rui Bai, Hairui Sun, Feng Lan, Zhang Hongjia, Yihua He
(Osaka University) Mesenchymal stem cell (MSC) therapy has shown promising results in the treatment of conditions ranging from liver cirrhosis to retinal damage, but results can be variable. Using a mouse heart failure model, researchers led by Osaka University found that levels of a fat cell-derived hormone called adiponectin in the host significantly affect the efficacy of MSC therapy. Administration of a drug that increases adiponectin in combination with MSCs is therefore likely to significantly improve the clinical outcome.
Contributors : Shoichi Ukai ; Naoya SakamotoSeries Type : Expression profiling by arrayOrganism : Homo sapiensTo understand the molecular basis of the acquisition of 5-FU resistance in gastric cancer stem cells, we established 5-FU-resistant gastric cancer organoids.We used microarrays to detail the global program of gene expression underlying 5-FU resistance and maintenance of stem cell properties in gastric cancer.
Contributors : Delong Feng ; Zhaoqiang LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo explore the role of Satb1 in rearrangement and repertoire of TCR genes, we used Satb1contional knockout micwhich the Satb1 gene was deleted in long term hematopoietic stem cells. We applied 5 ʹRACE (rapid amplification of cDNA ends) PCR technique to generate deep sequencing libraries of Tcrd, Tcrg, Tcrb, and Tcra cDNA by using a single set of primers for each TCR gene. We obtained millions of TCR sequences and unraveled the complexity of T-cell diversity. Our experimental evidence demon strate...
In this study, we have utilized a single-cell RNA-Sequencing platform coupled with transgenic lineage tracing in order to follow the progression of different embryonic neural stem cell populations as they progress into adult dormant neural stem cells. We show that adult dormant V-SVZ neural stem cells of different embryonic origins share a common molecular signature and reacquire an embryonic precursor-like state when activated to make new neurons in the adult brain.
Mesenchymal stem cells (MSCs) have emerged as a cell-based therapy in many diseases including atherosclerosis (AS) due to their capability of immunomodulation and tissue regeneration. However, the pathway for MSCs ’ antiatherosclerotic activity remains to be elucidated. Here, we test the hypothesis that microRNA-221 (miR-221) from MSC-derived extracellular vesicles (EVs) alleviates AS. Male ApoE−/− mice were fed a high-fat diet for 12 weeks to induce AS, and were then treated with human bone marrow mese nchymal stem cell (hBMSC)-derived EVs by tail vein injection.
ConclusionThese findings facilitate understanding the molecular mechanism of hBMMSCs differentiation and bring up a novel sight for postmenopausal osteoporosis therapy.