Clinical Case Management - Locally Advanced Penile Cancer

I am presenting a patient at tumor board with penile cancer. I have treated a couple of these in residency but there is some disagreement between myself and the other radiation oncologist here on field design, so I would like to see what other people would do. Diagnosis: Invasive moderately differentiated squamous cell carcinoma Staging: pT3 (invasion of corpora cavernosa), pN3 (ENE), cM0 (by PET) Previous treatment/workup: Biopsy and penectomy with right inguinal lymph node... Clinical Case Management - Locally Advanced Penile Cancer
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Radiation Oncology Source Type: forums

Related Links:

Conclusions: The SLNB using radiotracer can be a useful method for lymph node staging in patients with penile cancer and nonpalpable lymph nodes when performed in experienced centers.
Source: Indian Journal of Urology - Category: Urology & Nephrology Authors: Source Type: research
ConclusionsOSS is associated with a higher local recurrence rate compared to penectomy, yet it has no negative impact on overall and metastasis-free survival.
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
Authors: Marchioni M, Berardinelli F, De Nunzio C, Spiess P, Porpiglia F, Schips L, Cindolo L Abstract Penile cancer is a rare disease. Most of penile cancer are squamous cell carcinoma. Diagnosis is based on self-examination, clinical examination and confirmatory biopsy. Several imaging technique could be used for staging purpose. However, the best modality for staging in intermediate and high risk patients is by surgical evaluation and the use of inguinal lymph node dissection, that has also a therapeutic effect. Unfortunately, inguinal lymph node dissection is underused. Penile cancer treatment may have a major ...
Source: Minerva Urologica e Nefrologica - Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research
CONCLUSIONS: Integrated parts of HPV (E6 and E7 fractions) have been previously found in cervical, head and neck, anal and penile cancers. Conversely, although the evidence of concomitant HPV infection, integrated viral genome in cancer cells DNA had never been demonstrated in all the other genito-urinary tract cancers, and its role in the tumor genesis remain still largely debated. This is the reason because HPV infection should be tested in all patients with genito-urinary cancer to better investigate about its potential role in the tumor genesis and development . Moreover HPV infection option should be kept in mind when...
Source: Minerva Urologica e Nefrologica - Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research
Conclusions DSNB has excellent performance characteristics in staging cN0 patients, with high sensitivity and a low morbidity rate. Inguinal lymph node staging in penile cancer is the single most important prognostic indicator in patients with clinically impalpable disease. Sentinel node biopsy is a procedure with low morbidity and high sensitivity that is increasingly being adopted for staging purposes.
Source: European Urology Supplements - Category: Urology & Nephrology Source Type: research
Conclusion The occurrence of myiasis in the genitalia is more common in patients with precarious hygienic practices and low socio-economic level. The treatment option varied according to the primary tumor presentation and clinical lymph node status.
Source: International Braz J Urol - Category: Urology & Nephrology Source Type: research
A 68-year-old man presented with synchronous metastatic penile and prostate cancer. 68Ga-labeled prostate-specific membrane antigen-targeted ligand positron emission tomography/computed tomography (PSMA-PET/CT) revealed tracer uptake in inguinal, pelvic, and retroperitoneal metastases. Lymph node biopsies and immunohistochemical staining revealed that both cancers involved the lymph nodes and expressed PSMA. In the deposits of penile squamous cell carcinoma, PSMA expression was seen in tumor vessels and may explain the PSMA-PET/CT positivity of inguinal nodes involved in squamous cell carcinoma.
Source: Urology - Category: Urology & Nephrology Authors: Tags: Images in Clinical Urology Source Type: research
ConclusionPatients with impalpable inguinal lymph nodes undergoing DSNB with ≥G2 T1 disease should ideally have bilateral visualization of the sentinel lymph nodes, reflecting the drainage pattern from the primary tumour. In the present series, 12% of patients were found to have unilateral non‐visualization after DSNB. Among patients offered a repeat DSNB at a later date, localizing the sentinel node was successful in 86% of cases. Patients with favourable histological characteristics can be placed on clinical surveillance. Those with high‐risk disease can be offered a repeat DSNB procedure on the proviso that SML m...
Source: BJU International - Category: Urology & Nephrology Authors: Tags: Original Article Source Type: research
CONCLUSIONS: The treatment of penile cancer is usually surgical possibly in combination with chemotherapy in the presence of lymph node extension. The main prognostic factor is lymph node involvement, requiring appropriate management at the time of diagnosis.x © 2016 Elsevier Masson SAS. All rights reserved. PMID: 27846930 [PubMed - in process]
Source: Progres en Urologie - Category: Urology & Nephrology Tags: Prog Urol Source Type: research
Purpose of review: Prognosis of penile squamous cell cancer (PeSCC) depends on the involvement of the groin(s) as first step. We introduce the current available evidences that should rule the use of surgery in the management of PeSCC. Recent findings: Prophylactic inguinal node dissection in patients with no palpable nodes associates with immediate and long-term side-effects in up to 70% of patients. Recent findings support selective intervention based on early identification of dynamic sentinel node biopsy (DSNB) with false negative rate of 4–12%. Adequate node retrieval and extending surgery to the pelvis have bee...
Source: Current Opinion in Urology - Category: Urology & Nephrology Tags: METASTASIS SURGERY: Edited by Axel Heidenreich Source Type: research
More News: Cancer | Cancer & Oncology | Carcinoma | Penile Biopsy | Penile Cancer | Residencies | Skin Cancer | Squamous Cell Carcinoma | Students | Universities & Medical Training