Compartmental analysis of T cell clonal dynamics as a function of pathologic response to neoadjuvant PD-1 blockade in resectable non-small cell lung cancer.

CONCLUSIONS: Our study suggests that exchange of T cell clones between tumor and blood represents a key correlate of pathologic response to neoadjuvant immunotherapy, and shows that the periphery may be a previously underappreciated originating compartment for effective anti-tumor immunity.
PMID: 31754049 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - November 20, 2019 Category: Cancer & Oncology Authors: Zhang J, Ji Z, Caushi JX, El Asmar M, Anagnostou V, Cottrell TR, Chan HY, Suri P, Guo H, Merghoub T, Chaft JE, Reuss JE, Tam AJ, Blosser RL, Abu-Akeel M, Sidhom JW, Zhao N, Ha JS, Jones DR, Marrone KA, Naidoo J, Gabrielson E, Taube JM, Velculescu VE, Brah Tags: Clin Cancer Res Source Type: research