Differential effects of atrial and brain natriuretic peptides on human pulmonary artery: An in vitro study.

CONCLUSION: BNP could be acting as a partial agonist in small human pulmonary arteries, and inhibits relaxation to ANP. Elevated levels of circulating BNP could be responsible for the worsening of decompensated heart failure. This finding could also explain the disappointing results seen in clinical trials of ANP and BNP analogues for the treatment of heart failure. PMID: 31754411 [PubMed]

https://www.ncbi.nlm.nih.gov/pubmed/31754411?dopt=Abstract

Source: World Journal of Cardiology - October 25, 2019 Category: Cardiology Authors: Hussain A, Bennett RT, Tahir Z, Isaac E, Chaudhry MA, Qadri SS, Loubani M, Morice AH Tags: World J Cardiol Source Type: research