A transmural gradient of myocardial remodeling in early-stage heart failure with preserved ejection fraction in the pig.

In conclusion, cardiomyocyte changes due to DOCA were similar in subepicardial, midmyocardial and subendocardial regions but DOCA-induced changes in the interstitium appeared to be more pronounced in the subendocardial ventricular wall layers. This suggests a pivotal role of the subendocardial interstitium in the pathogenesis of HFpEF. PMID: 31749243 [PubMed - as supplied by publisher]
Source: Journal of Anatomy - Category: Anatomy Authors: Tags: J Anat Source Type: research