Immunomodulatory Effects of Vitamin D in Pregnancy and Beyond

This article reviews the immunomodulatory role of vitamin D in autoimmune diseases and pregnancy. In particular, we will describe the role of vitamin D from conception until delivery, including the health of the offspring. This review highlights an observational study where hypovitaminosis D was correlated with decreased fertility, increased disease activity, placental insufficiency, and preeclampsia in women with APS.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research

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Authors: Kalmarzi RN, Ahmadi S, Rahehagh R, Fathallahpour A, Khalafi B, Kashefi H, Roshani D, Zaryan RN, Mohamadi S, Kooti W Abstract BACKGROUND: The extensive impacts of vitamin D on the immune system has gathered the attention of scholars in last years. In this regard, studies about vitamin D and incidence of asthma have showed various results. The aim of this study was to evaluate the effect of vitamin D supplements on clinical outcomes in asthmatic children with vitamin D insufficiency. MATERIALS &METHODS: This before-after interventional study was conducted on all asthmatic children who attended the Be...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research
This article describes a model of human induced pluripotent stem cell cardiomyocyte-derived engineered heart tissues (hiPSC-CM EHTs) transduced with the calcium sensor GCaMP6f followed by sequential analysis of force and CaT. Average peak analysis demonstrated the temporal sequence of the CaT preceding the contraction twitch. The pharmacological relevance of the test system was demonstrated with inotropic indicator compounds. Force-frequency relationship was analyzed in the presence of ivabradine (300 nM), which reduced spontaneous frequency and unmasked a positive correlation of force and CaT at physiological human h...
Source: Stem Cell Reports - Category: Stem Cells Source Type: research
This study investigated the protective effects of ascorbic acid in combination with calcitriol on airway remodelling in ovalbumin (OVA)-induced chronic asthma.Materials and methods: BALB/c mice were assigned into seven groups: (1) Control; (2) Asthma; (3) Ineffective C (orally 39 mg/kg ascorbic acid); (4) Ineffective D (intraperitoneally 1.5 μg/kg calcitriol); (5) Effective C (orally 130 mg/kg ascorbic acid); (6) Effective D (intraperitoneally 5 μg/kg calcitriol); (7) Combination (orally 39 mg/kg ascorbic acid + intraperitoneally 1.5 μg/kg calcitriol). All an...
Source: Pharmaceutical Biology - Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research
In this study, Three-dimensional porous scaffolds made of Mg/Al-layered double hydroxide (LDH)/polycaprolactone (PCL) nanocomposites with different LDH contents have been prepared for bone tissue engineering applications. The microspheres-aggregated nanocomposite scaffolds were fabricated by freeze-drying and particulate leaching methods. The size of the microspheres ranges from 13 μm to 58 μm, in which the minimum microsphere size was achieved in the PCL scaffold with 0.1 wt% LDH. The hydrophilicity of the scaffolds was improved by the incorporation of LDH nanoparticles as demonstrated by the water contact ang...
Source: Materials Today Communications - Category: Materials Science Source Type: research
Publication date: June 2020Source: Materials Today Communications, Volume 23Author(s): Irene Lodoso-Torrecilla, Floris Stumpel, John A. Jansen, Jeroen J.J.P. van den BeuckenAbstractThe incorporation of poly(DL-lactic-co-glycolic acid) (PLGA) particles into calcium phosphate cements (CPCs) is an effective strategy to enhance CPC macroporosity and degradation. However, bone regeneration is hindered until hydrolytic PLGA degradation starts a few weeks after implantation. Additionally, CPC and CPC/PLGA injectability and cohesion are suboptimal. In the current study, poly(N-vinylpyrrolidone) (PVP), a water-soluble polymer, was ...
Source: Materials Today Communications - Category: Materials Science Source Type: research
This study reports the synthesis of the BiVO4/TiO2 nanocomposite in optimized conditions using the hydrothermal route. By varying many experimental parameters such as the temperature, the hydrothermal reaction time, the pH of the solution and the surfactant’s nature, we have successfully obtained BiVO4 (monoclinic)/TiO2 (anatase) nanomaterials with different morphologies. These materials were characterized by X-ray powder Diffraction (XRD), Infrared Spectroscopy (IR) and Scanning Electron Microscopy (SEM). The as-prepared nanocomposites were employed to manufacture hybrid electrode sensors to detect H2O2. The BiVO4/T...
Source: Materials Research Bulletin - Category: Materials Science Source Type: research
CONCLUSIONS Anterior cruciate ligament suture with the InternalBrace ligament augmentation judging from the results achieved by our group of patients brings very good clinical outcomes already at 6 months postoperatively. This method allows the athletes to return to full load soon. It maintains the kinematics and knee joint proprioception, and thus can potentially contribute to the prevention of post-traumatic arthritis. Strict application of indication criteria is a precondition to success. A longer follow up and evaluation of a larger number of patients will, however, be necessary to definitely confirm the success of thi...
Source: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca - Category: Orthopaedics Tags: Acta Chir Orthop Traumatol Cech Source Type: research
CONCLUSIONS The operative treatment of displaced intra-articular fractures consisting of open reduction from extended lateral approach and internal calcaneal LCP fixation brings good results. We concluded that there is no statistically significant difference in the results of osteosynthesis with a locking plate alone and combined with augmentation of diaphyseal defect of the calcaneus. Filling of the diaphyseal defect in the calcaneus is not necessary, it neither accelerates the healing, nor brings better treatment outcomes Key words: calcaneal fracture, cement augmentation of defect, locking plate, extended lateral approa...
Source: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca - Category: Orthopaedics Tags: Acta Chir Orthop Traumatol Cech Source Type: research
This article reviews the structure, biochemical composition and functions of the synovial membrane and by focusing on the role of synovial fibroblasts explains key features of articular tissue remodelling particularly under disease conditions.
Source: Seminars in Cell and Developmental Biology - Category: Cytology Source Type: research
Publication date: Available online 16 January 2020Source: CellAuthor(s): Qian Lin, Jason Manley, Magdalena Helmreich, Friederike Schlumm, Jennifer M. Li, Drew N. Robson, Florian Engert, Alexander Schier, Tobias Nöbauer, Alipasha VaziriSummaryGoal-directed behavior requires the interaction of multiple brain regions. How these regions and their interactions with brain-wide activity drive action selection is less understood. We have investigated this question by combining whole-brain volumetric calcium imaging using light-field microscopy and an operant-conditioning task in larval zebrafish. We find global, recurring dyn...
Source: Cell - Category: Cytology Source Type: research
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