KIR2DS4, KIR2DL2, and KIR2DS4del are linked with basaloid tumors, lymph node metastasis, advanced stage and metastatic risk in head and neck squamous cell carcinoma.

CONCLUSION: In HNSCC, KIR2DL2 is positively while KIR2DS4 is negatively associated with advanced stage. The higher proportion of LNM in carriers of KIR2DL2 and carriers of 5 iKIRs, suggested that inhibitory KIRs are associated with metastatic risk. PMID: 31751561 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31751561?dopt=Abstract

Source: Experimental and Molecular Pathology - November 17, 2019 Category: Pathology Authors: Barani S, Khademi B, Ghaderi A Tags: Exp Mol Pathol Source Type: research