Tuberculosis and gastrectomy : A Nationwide Population-based Matched Cohort Study

The objective of this study was to examine the incidence and risk of tuberculosis in patients who underwent gastrectomy in Korea, an intermediate tuberculosis burden country. This population-based matched cohort study was conducted to analyze the sample database of the National Health Insurance Corporation. There were 3898 subjects with having gastrectomy as the gastrectomy group between 2004 and 2012, and 15,592 randomly selected matched subjects without gastrectomy as the non-gastrectomy group. Subjects with history of pulmonary tuberculosis before the index date 2 year were excluded. Both gastrectomy and non-gastrectomy groups were matched with sex, age, Diabetes, end stage renal disease, transplantation, Chronic obstructive pulmonary disease and pneumoconiosis. The incidence of tuberculosis was assessed in both groups. The multivariable Cox proportional hazards regression model was used to assess the hazard ratio and 95% confidence interval for risk of tuberculosis associated with gastrectomy. The overall incidence of tuberculosis was 2 fold greater in the gastrectomy group than that in the non-gastrectomy group. After adjusting for confounding factors, the adjusted hazard ratio of tuberculosis was 1.93 (95% CI 1.44-2.59) for the gastrectomy group, compared with the non-gastrectomy group. Especially, the hazard ratio was 2.4 for the total gastrectomy group. Old age and diabetes was other factors that could be related to pulmonary tuberculosis. Careful monitoring and timel...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Tuberculosis Source Type: research