Cardiovascular and metabolic events in the MOSAIC randomised controlled trial: 5-year follow-up data

Discussion: From 2 to 5 years of follow-up CPAP did not significantly reduce the number of patients who actually had CV or metabolic events in the MOSAIC trial. Therefore, whilst CPAP reduces daytime sleepiness, it cannot be recommended as a treatment to reduce CV or metabolic events in patients with minimally symptomatic OSA.References:1. PMID 23111478.2. PMID 24508706
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Sleep and control of breathing Source Type: research

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Publication date: Available online 23 January 2020Source: Pharmacological ResearchAuthor(s): Shabnam Radbakhsh, Thozhukat Sathyapalan, Maciej Banach, Amirhossein SahebkarAbstractMicroRNAs (miRNA) are one class of the small regulatory RNAs that can impact the expression of numerous genes including incretin hormones and their G protein-coupled receptors. Incretin peptides, including GLP-1, GLP-2, and GIP, are released from the gastrointestinal tract and have an crucial role in the glucose hemostasis and pancreatic beta-cell function. These hormones and their analogs with a longer half-life, glucagon like peptide-1 receptor a...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Combining weight-bearing exercise with aerobic pursuits was the most effective way to reduce the likelihood of developing obesity in a massive survey of 1.7 million US adults.Medscape Medical News
Source: Medscape Emergency Medicine Headlines - Category: Emergency Medicine Tags: Diabetes & Endocrinology News Source Type: news
Conclusions: Hyperuricemia and hypertension may have a synergistic interaction towards renal function loss in addition to their independent impacts. Our findings may provide a straightforward illustration which is easy for the public to realize the hazard of coexistent hypertension and hyperuricemia on renal injury. PMID: 31962051 [PubMed - as supplied by publisher]
Source: Postgraduate Medicine - Category: Internal Medicine Tags: Postgrad Med Source Type: research
This study investigated whether RIPreC and RIPostC exerted neuroprotection against cerebral ischemic injury in type 2 diabetic mice. RIPreC (24 h before ischemia) and RIPostC (immediately after reperfusion) were performed in an ischemia/reperfusion induced stroke model with type 2 diabetes. Ischemic outcomes, flow cytometry, multiplex cytokine assay, and western blotting were analyzed after 45 min of ischemia followed by 48 h of reperfusion. Our data indicated that RIPreC and RIPostC attenuated cerebral injuries and neurological deficits. RIPreC significantly reduced CD4 T cell and CD8 T cell infiltration and increas...
Source: Neurochemistry International - Category: Neuroscience Source Type: research
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Source: Cranio - Journal of Craniomandibular and Sleep Practice - Category: Sleep Medicine Authors: Source Type: research
Authors: Tieri M, Ghelfi F, Vitale M, Vetrani C, Marventano S, Lafranconi A, Godos J, Titta L, Gambera A, Alonzo E, Sciacca S, Riccardi G, Buscemi S, Del Rio D, Ray S, Galvano F, Beck E, Grosso G Abstract Whole grains have been associated with a number of health benefits. We systematically reviewed existing meta-analyses of observational studies and evaluated the level of evidence for their putative effects based on pre-selected criteria. Of the 23 included studies, we found convincing evidence of an inverse association between whole grain consumption and risk of type-2 diabetes and colorectal cancer; possible evid...
Source: International Journal of Food Sciences and Nutrition - Category: Nutrition Tags: Int J Food Sci Nutr Source Type: research
Psychological and behavioral strategies around self-monitoring and coping with cravings may underlie the success of commercial weight management programs and should be learned from, say US scientists.Medscape Medical News
Source: Medscape Psychiatry Headlines - Category: Psychiatry Tags: Diabetes & Endocrinology News Source Type: news
The majority of doctors will tell you that there is nothing you can do to reverse fatty liver and that health problems such as cirrhosis and liver failure may be in your future that they will address with the awful “solution” of liver transplant. The truth is the opposite: fatty liver is easily and readily reversible in virtually everybody, provided you take action before irreversible changes take place and are given the right information and tools. In this video, I discuss the three basic phenomena that drive fat deposition, liver damage, and inflammation that lead to this condition: Carbohydrate consumption ...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Open bowel flora carbohydrates carbs Inflammation NAFLD nash triglycerides undoctored wheat belly Source Type: blogs
Authors: Chekalina NI, Burmak YH, Petrov YY, Borysova ZO, Trybrat TA, Shut SV, Kazakov YM Abstract OBJECTIVE: The aim of the research was to determine the dependence of the blood flow velocity in the thyroid arteries in patients with Autoimmune Thyroiditis (AIT) on the presence of atherosclerotic carotid disease and the level of systemic blood pressure. METHODS: The research involved 20 patients with AIT in euthyroid state, 30 patients AIT in euthyroid state with stable Coronary Heart Disease (CHD), 30 patients with stable CHD and 30 healthy individuals. Participants of the research were examined using ultrasou...
Source: Current Medical Imaging Reviews - Category: Radiology Tags: Curr Med Imaging Rev Source Type: research
Conclusions: This is the first meta-analysis investigating adjuvant PNP therapy for DKD. PNP apparently exerted beneficial effects on kidney function and improved the metabolism of serum lipids by CM. Further, well-conducted, high-quality trials on DKD patients are needed to provide high-quality evidence. PMID: 31967924 [PubMed - in process]
Source: Pharmaceutical Biology - Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research
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