Long-term follow-up data about chronic thromboembolic disease

Backgrounds: Chronic thromboembolic disease (CTED) is characterized by similar symptoms and perfusion defect as chronic thromboembolic pulmonary hypertension (CTEPH), but without pulmonary hypertension at rest. Recently, successful pulmonary endarterectomy (PEA) and balloon pulmonary angioplasty (BPA) for symptomatic patients with CTED has been reported. However, it remains unclear whether CTED evolves to CTEPH. The aim of this study is to clarify the natural history of CTED.Methods: Consecutive patients diagnosed as CTED between 1986 and 2017 were retrospective enrolled. CTED was defined as follows: a mean pulmonary arterial pressure at rest
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Pulmonary hypertension Source Type: research

Related Links:

Abstract BACKGROUND: Although cardiac troponin and natriuretic peptide have been shown to decrease after balloon pulmonary angioplasty (BPA) with improved right ventricular afterload in chronic thromboembolic pulmonary hypertension (CTEPH), biomarkers to evaluate the effects of BPA independently of heart failure status remain to be developed. METHODS: In 39 consecutive CTEPH patients including 31 who underwent BPA, we measured plasma levels of cyclophilin A (CyPA), which we demonstrated is secreted from pulmonary vascular smooth muscle cells in response to mechanical stretch and hypoxia. RESULTS: CyPA le...
Source: Journal of Cardiology - Category: Cardiology Authors: Tags: J Cardiol Source Type: research
We read with great interest the article by Ma and colleagues1 about elevated gradient after mitral valve repair and the effect of surgical technique and relevance of postoperative atrial fibrillation. Elevated transmitral gradient may cause not only delayed atrial fibrillation but also all other complications associated with pure mitral stenosis, such as left atrial enlargement, thromboembolism, secondary pulmonary hypertension, and delayed right heart failure. In the article of Ma and colleagues,1 the elevated pressure gradient after mitral annuloplasty was due to 2 main surgical problems: the use of small, complete, semi...
Source: The Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Letter to the Editor Source Type: research
Chronic thromboembolic pulmonary hypertension (CTEPH) is characterized by chronic thrombi in the pulmonary arteries, causing pulmonary hypertension and right heart failure. Early and accurate diagnosis are essential for successful treatment but are often difficult because clinical signs and symptoms can be nonspecific and risk factors, such as history of venous thromboembolism, may not always be present. Here, we report a case involving a 76-year-old woman who demonstrated paradoxical cerebral embolism as the initial manifestation of CTEPH.
Source: Journal of Stroke and Cerebrovascular Diseases - Category: Neurology Authors: Tags: Case Report Source Type: research
This article summarizes the current research progress in CTEPH pathogenesis from the perspective of risk factors related to medical history, abnormal coagulation and fibrinolytic mechanisms, inflammatory mechanisms, genetic susceptibility factors, angiogenesis, in situ thrombosis, vascular remodeling, and other aspects.
Source: Heart Failure Reviews - Category: Cardiology Source Type: research
Conclusions: A significant number of TI patients have high LIC, short stature and endocrine disorders. Patients who require occasional transfusions have more liver iron overload and higher hepatic dysfunction. Females appear to attain better final adult height and have higher IGF1- SDS versus males. Our data emphasize the need for long term surveillance for identification of organ-specific risk factors and early disease manifestations.We also recommend a close monitoring of endocrine and other complications, according to the international guidelines.
Source: Mediterranean Journal of Hematology and Infectious Diseases - Category: Hematology Source Type: research
Obstructive lesions to the pulmonary circulation present with nonspecific symptoms varying from chest pain, dyspnea on exertion, and cough to florid right heart failure.1 Congenital pulmonic stenosis, pulmonary embolism (PE), and chronic thromboembolic pulmonary hypertension (CTEPH) are common etiologies.2 Primary tumors of the pulmonary vasculature are less common and more likely occur owing to metastatic involvement.3 Given the rarity of these tumors, their presentation commonly is misdiagnosed, and patients commonly are treated for chronic thromboembolism.
Source: Journal of Cardiothoracic and Vascular Anesthesia - Category: Anesthesiology Authors: Tags: E-Challenge Source Type: research
Publication date: Available online 13 March 2019Source: The Annals of Thoracic SurgeryAuthor(s): Tomohito Kanzaki, Satoshi Numata, Sachiko Yamazaki, Hitoshi YakuAbstractA 75-year-old woman was referred to our hospital for dyspnea and edema of the lower limbs. Computed tomography angiography revealed a dilated left coronary artery from the left main trunk to the left circumflex branch and a dilated fistula originating from the left circumflex branch and draining into the persistent left superior vena cava. Physical examination revealed pulmonary hypertension and congestive heart failure. We performed closure of the fistula ...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
AbstractPurpose of ReviewMultiple myeloma is a common hematologic malignancy characterized by recurrent relapsing disease course requiring use of various therapies. Over the past few decades, significant advancements in the treatment of myeloma have occurred including routine use of proteasome inhibitors and immunomodulatory drugs. These have effectively improved survival; however, some also have increased risk of cardiovascular toxicity. Here, we will review the incidence, pathophysiology, and management of cardiovascular complications associated with antimyeloma agents.Recent FindingsCardiovascular complications associat...
Source: Current Oncology Reports - Category: Cancer & Oncology Source Type: research
Background: While novel agents have allowed for successful outpatient treatment of patients with multiple myeloma (MM), multi-agent infusional chemotherapy regimens continue to have a role, particularly in high burden disease states. However, the use of platinum-based regimens is limited in patients with renal insufficiency and renal failure. We have been using a modified hyperCVAD regimen, termed HyperCD (Table 1), with omission of vincristine, and inclusion of a proteasome inhibitor (PI, either bortezomib or carfilzomib) in these aggressive clinical presentations for rapid tumor reduction. Here we present our experience ...
Source: Blood - Category: Hematology Authors: Tags: 653. Myeloma: Therapy, excluding Transplantation: Poster II Source Type: research
Background: Chronic thromboembolic pulmonary hypertension (CTEPH) is a type of pulmonary hypertension (PH) that leads to right heart failure. Patients with CTEPH may also have a psychiatric disorder. Antipsychotic drugs are known to increase the risk of thromboembolism in the acute setting; however, the relationship between CTEPH and psychiatric illness is unclear.Methods: We retrospectively identified 227 consecutive patients (156 women, mean age 58.0 ± 12.5 years) who underwent right heart catheterization because of a diagnosis or suspicion of CTEPH. The patients were categorized according to whether they did or d...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Pulmonary hypertension Source Type: research
More News: Angioplasty | Baloon Angioplasty | Cardiology | Heart | Heart Failure | Hypertension | Perfusion | Pulmonary Hypertension | Pulmonary Thromboembolism | Respiratory Medicine | Study | Thrombosis