Effects of Sustained and Intermittent Hypoxia on Human Lung Cancer Cells

Introduction: The relationship between lung cancer and COPD is well known. Recent clinical studies found a higher prevalence of obstructive sleep apnea (OSA) in patients suffering lung cancer. Although hypoxia has been suggested to be one of the main factors associated with lung malignancy, most studies addressing this topic have limitations due to the reduced number of patients recruited and because lung cancer has been analyzed avoiding its complexity in terms of different histotypes.Aim: to investigate the effect of different patterns of hypoxia on cells of the most prevalent histological sub-types of non-small cell lung cancer: adenocarcinoma (ADC) and squamous cell carcinoma (SC).Methods: Four human lung cancer cell lines were exposed to normoxia (N) (13% O2), sustained hypoxia (SH) (7% O2), mild intermittent hypoxia mimicking OSA (MIH) (13% - 7% O2) and severe intermittent hypoxia (SIH) (7% - 4% O2) for 48 h and cell proliferation was quantified.Results: SIH pattern enhanced the proliferation of H520 (SC) (~66%, p
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Sleep and control of breathing Source Type: research

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 DOI: 10.3779/j.issn.1009-3419.2020.01.06
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