Frequent adverse events during prolonged Bedaquiline treatment on XDR-tuberculosis patients

Background: Drug resistance tuberculosis is a global health problem. Many countries are using Bedaquiline for the treatment of XDR-tuberculosis.Aim of the study: Comparing the frequency of adverse events (AE) on XDR-tuberculosis patients with a standard and prolonged course of treatment.Methods: Prospective study from 2012 to 2018. 148 patients diagnosed with XDR-tuberculosis pulmonary were treated with Bedaquiline. 28 patients had bilateral destruction in the lungs, prolonged bacterial excretion, a prolonged course was applied to them Bedaquiline 44-48 weeks (group 1). 120 patients received a standard (24 weeks) course Bedaquiline(group 2). All patients received basic regiment for 24 months. The frequency of all AE, which during the course Bedaquiline treatment in patients of groups 1 and 2 regardless of the connection with its reception.Results: Patients of group 1 had AE: eosinophilia -11 cases (39,3%), arthralgia-10(35,7%), diarrhea-7(25%), nausea-6(21,4%), elevation uric acid-4 (14,3%), interval lengthening QT-2 (7,1%), elevation transaminase-1 (3,6%). Patients of the 2 groups were AE: eosinophilia–46 cases (38,3%)(p1-2>0,1), arthralgia–52(43,3%)(p1-2>0,1), nausea–34 (28,3%)(p1-2>0,1), diarrhea–29(24,2%)(p1-2>0,1), elevation uric acid–20(16,7%)(p1-2>0,1), interval lengthening QT–11(9,2%)(p1-2>0,1), elevation transaminase–23 (19,2%)(p1-2
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Tuberculosis Source Type: research

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