Do causes influence clinical, functional and quality of life aspects on patients with bronchiectasis not associated with cystic fibrosis?

Bronchiectasis can have different causes. Etiology impact on clinical and functional aspects is little known.Objectives: Identify causes of bronchiectasis non cystic fibrosis(BNFC) and investigate if there are differences concerning clinical, functional and of quality of life(QoL) among groups.Methods: Descriptive and cross-sectional study conducted in a Brazilian University hospital. Patients (N=109, mean age 53 yrs, 60% women) with tomographic diagnosis of bronchiectasis had medical files reviewed and were interviewed to identify personal and familial antecedents; they also performed spirometry and answered the Saint George QoL questionnaire(SGRQ).Results: mean values: FVC:64%; FEV1:53%; BMI:26kg/m2, SGRQ score:45%. Cardiovascular diseases, dyslipidemia and diabetes were present in 36%, 5% and 16%, respectively. Apart from 26% of the cases with undetermined cause, other causes were post-infectious(23%), ciliary dyskinesia(CD)(16%), COPD(15%), and immunodeficiency(7%). Of all antecedents surveyed, only pneumonia before 10 years-old was associated with diagnosis, being more frequent in CD and idiopathic groups(p=0.02). There was an age difference: COPD patients were older(65 yrs) and CD ones, younger (43 yrs)(p=0.005). COPD subjects had worse pulmonary function (p=0.014) and more dyslipidemia(p=0.056). Differing from other groups(p
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Monitoring airway disease Source Type: research

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This article attempts to aid clinicians in using diabetes devices in their clinical practice. It reviews device selection, initiation, and follow-up. It discusses work flow in an office and provides tips on billing. It stresses the need for patient choice, education, and on-going support through downloading and interpretation of data to optimize care. PMID: 31980122 [PubMed - in process]
Source: The Medical Clinics of North America - Category: General Medicine Authors: Tags: Endocrinol Metab Clin North Am Source Type: research
Authors: Fournier E Abstract Carpal tunnel syndrome (CTS) is too common a condition not to daily interact with the practitioner, if only because of its entanglement to other pathologies, causal or chance association. The typical symptomatology, with hand paresthesia and morning pain upon waking, is related to a median nerve injury in the confined space of the carpal tunnel, more often by local inflammation and tenosynovitis of the finger flexors (repetitive activity of the hands). SCC may be secondary to situations (pregnancy) or conditions (edema, hypothyroidism…), which exaggerate the ordinary pathophysiol...
Source: Revue de Medecine Interne - Category: Internal Medicine Tags: Rev Med Interne Source Type: research
ConclusionsHigher concentrations of triclosan, BP-3, and propyl, butyl, ethyl, and methyl parabens were associated with lower odds of diabetes. These findings warrant further investigation into the potential mechanism behind the observed associations and the temporal direction of the associations, given that we cannot rule out reverse causation. Future studies of these endocrine disruptors may improve the understanding of their relationship with diabetes.
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
In this study we have genetically modified a serotype 1 strain (519/43), the first time that this has been achieved for this serotype, providing the methodology for a deeper understanding of its biology and pathogenicity. As proof of principle we constructed a defined pneumolysin mutant and showed that it lost its ability to lyse red blood cells. We also showed that when mice were infected intranasally with the mutant 519/43Δply there was no significant difference between the load of bacteria in lungs and blood when compared to the wild type 519/43. When mice were infected intraperitoneally there were significantly f...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
This study represents the first large scale attempt to gather a long period information on Q fever infection in Greece. The findings of the current study support the fact that Q fever is an important endemic zoonotic disease in Greece and needs increased awareness by clinical physicians and health care system.
Source: Comparative Immunology, Microbiology and Infectious Diseases - Category: Infectious Diseases Source Type: research
AbstractPurpose of ReviewDiabetes is a common and prevalent medical condition as it affects many lives around the globe. Specifically, type-2 diabetes (T2D) is characterized by chronic systemic inflammation alongside hyperglycemia and insulin resistance in the body, which can result in atherosclerotic legion formation in the arteries and thus progression of related conditions called diabetic vasculopathies. T2D patients are especially at risk for vascular injury; adjunct in many of these patients, their cholesterol and triglyceride levels reach dangerously high levels and accumulate in the lumen of their vascular system.Re...
Source: Current Pathobiology Reports - Category: Laboratory Medicine Source Type: research
ConclusionCongenital piriform sinus fistula is an important cause of deep neck abscess in children. The presence of purulent gas-liquid equilibrium or air shadow in cervical-enhanced computed tomography or ultrasound suggests a high possibility of the presence of an internal fistula, and endoscopic low temperature ablation can be done at the same time as the diagnostic endoscopy.ResumoIntroduçãoA fístula congênita do seio piriforme é uma doença relativamente rara na prática clínica; a maioria se manifesta na infância; entretanto, os médicos geralmente t&ec...
Source: Brazilian Journal of Otorhinolaryngology - Category: ENT & OMF Source Type: research
ConclusionsPillar suture combined with tonsillectomy may reduce postoperative bleeding incidence despite increasing pillar edema in pediatric tonsillectomy. Postoperative pain-relief, palatal hematoma, palatal discomfort sensation, site infection, and velopharyngeal insufficiency were not significantly altered compared to tonsillectomy alone. However, further studies are needed to corroborate the results of this study.ResumoIntroduçãoDiversas técnicas cirúrgicas têm sido utilizadas na tonsilectomia no intuito de reduzir complicações.ObjetivosAvaliar os efeitos da sutura dos p...
Source: Brazilian Journal of Otorhinolaryngology - Category: ENT & OMF Source Type: research
Publication date: January–February 2020Source: Brazilian Journal of Otorhinolaryngology, Volume 86, Issue 1Author(s): Manal Al Bin Manie, Khalid Hussain Al-Qahtani, Ahmed Al Ammar, Tahera Islam, Faiza N. Al Otaibi
Source: Brazilian Journal of Otorhinolaryngology - Category: ENT & OMF Source Type: research
Publication date: January–February 2020Source: Brazilian Journal of Otorhinolaryngology, Volume 86, Issue 1Author(s): Michelle Manzini, Cláudia Schweiger, Denise Manica, Gabriel Kuhl
Source: Brazilian Journal of Otorhinolaryngology - Category: ENT & OMF Source Type: research
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