Effect of vaccination of pneumococcal infection on the course of chronic obstructive pulmonary disease in combination with diabetes mellitus

Objective: to evaluate the effect of conjugated pneumococcal vaccine Prevenar 13 on the course of COPD in combination with type 2 diabetes.The study included 76 patients with COPD III (40.8%) and COPD IV (59.2%) in combination with type 2 diabetes, 72 (94.7%) men and 4 (5.3%) women, averaga age 64.72 years. All patients were current or past smokers, the smoking index- 45.11. The duration of COPD was 8.71 years, the lasting of diabetes mellitus was 10.23 years. All patients were overweight, BMI=31.67 kg/m2. ±Before vaccination, patients reported severe clinical symptoms (CAT=27.99±3.79, CI 95% 19-36) and particularly severe dyspnea (mMRC=2.72±0.53, CI 95% 2-4), frequent exacerbations (3.45±0.85, CI 95% 2-5) episodes per year, in 33 (43.4%) with hospitalization and pneumonia in 17 (22.37%) patients.Three years after the PCV13 vaccination, the number of exacerbations of COPD significantly decreased by 1.47±0.71 (p
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Monitoring airway disease Source Type: research

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ConclusionsA vaccination strategy that omits pneumococcal conjugate vaccine in immunocompetent U.S. seniors may be economically reasonable, particularly for black seniors. Use of both pneumococcal vaccines was more effective but substantially more expensive.
Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
ConclusionsOne-third of local health departments reported no safety-net sexually transmitted disease services or were not aware of the services, and availability of specific services varied. Without an expansion of resources, local health departments might explore collaborations with healthcare systems and innovations in testing to expand sexually transmitted disease services.
Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
ConclusionsDifferences were observed in declines in the proportion of human papillomavirus 16/18 lesions by area-based measures since the introduction of human papillomavirus vaccines, with greater and earlier declines in areas with fewer residents living in poverty and racial minorities. Ongoing human papillomavirus vaccine impact monitoring is necessary to track differences by sociodemographic characteristics.
Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
Publication date: Available online 20 December 2019Source: Best Practice &Research Clinical Obstetrics &GynaecologyAuthor(s): Kelechi Njoku, Joanna Abiola, Johanna Russell, Emma J. CrosbieAbstractEndometrial cancer (EC) is the most common gynaecological malignancy, and its incidence is rising alongside the growing prevalence of obesity. Effective risk-reducing interventions hijacking the key mechanisms driving endometrial carcinogenesis may affect EC diagnoses if aimed at those at greatest risk. An understanding of the key risk factors and their role in tumourigenesis is critical in developing such prevention strat...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - Category: OBGYN Source Type: research
Macrophages are a type of innate immune cell, and like all immune cells are involved in a great many processes in the body, ranging from tissue regeneration to clearing out molecular waste and debris to destruction of pathogens. Macrophages, and the similar microglia of the central nervous system, adopt different phenotypes, known as polarizations, depending on environment and the task at hand. The M1 polarization is pro-inflammatory and focused on ingestion of pathogens and debris, while the M2 polarization is anti-inflammatory and focused on regeneration. These are broad buckets and as such not truly representative of th...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
Publication date: Available online 27 January 2020Source: The Lancet NeurologyAuthor(s): Franziska Hopfner, Günter U Höglinger, Gregor Kuhlenbäumer, Anton Pottegård, Mette Wod, Kaare Christensen, Caroline M Tanner, Günther DeuschlSummaryBackgroundβ-adrenoceptors are widely expressed in different human organs, mediate important body functions and are targeted by medications for various diseases (such as coronary heart disease and heart attack) and many β-adrenoceptor acting drugs are listed on the WHO Model List of Essential Medicines. β-adrenoceptor antagonists are used by billions ...
Source: The Lancet Neurology - Category: Neurology Source Type: research
In conclusion, the current study shed light on the potential neuroprotective role of metformin and trimetazidine in the amelioration of cognitive function via hindering inflammatory processes in diabetic epileptic rats.Graphical abstractDiagram illustrating alterations in the hippocampus induced in diabetic epileptic rats. DAP, death-associated protein; ATP/ADP, ratio of adenosine triphosphate and adenosine diphosphate; mTOR, mammalian target of rapamycin; Casp-3, caspase-3; TNF-α, tumor necrosis factor-α; IL-1β, interleukin-1β; NF-κB, nuclear factor-κB; IGF-1, insulin growth factor 1.
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Publication date: Available online 28 January 2020Source: Journal of Biomedical InformaticsAuthor(s): Akhilesh Kumar Bajpai, Sravanthi Davuluri, Kriti Tiwary, Sithalechumi Narayanan, Sailaja Oguru, Kavyashree Basavaraju, Deena Dayalan, Kavitha Thirumurugan, Kshitish K. AcharyaAbstractIn absence of periodic systematic comparisons, biologists/bioinformaticians may be forced to make a subjective selection among the many protein-protein interaction (PPI) databases and tools. We conducted a comprehensive compilation and comparison of such resources. We compiled 375 PPI resources, short-listed 125 important ones (both lists are ...
Source: Journal of Biomedical Informatics - Category: Information Technology Source Type: research
Publication date: Available online 28 January 2020Source: Journal of Biomedical InformaticsAuthor(s): Sisi Ma, Pamela J. Schreiner, Elizabeth R. Seaquist, Mehmet Ugurbil, Rachel Zmora, Lisa S. ChowAbstractThe presence of missing data at the time of prediction limits the application of risk models in clinical and research settings. Common ways of handling missing data at the time of prediction include measuring the missing value and employing statistical methods. Measuring missing value incurs additional cost, whereas previously reported statistical methods results in reduced performance compared to when all variables are m...
Source: Journal of Biomedical Informatics - Category: Information Technology Source Type: research
In this study, we investigated the effect of serum endotoxin on CD4 T cell inflammation. Age and sex-matched non-obese healthy subjects, subjects with non-alcoholic fatty liver (NAFL) but not steatohepatitis, and NASH patients were recruited for this study. The latter two groups were additionally matched in BMI and diabetes status. We first showed that compared to healthy subjects and NAFL patients, NASH patients presented significantly higher levels of serum endotoxin. Concurrently, NASH patients presented a Th17 bias that was associated with high endotoxin levels. To examine whether endotoxin could directly mediate IL-17...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
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