Gene expression of nociceptors in the esophagus of patients with gastro-esophageal reflux (GER)-associated chronic cough

Conclusions: Cough in GER patients is associated with the increased expression of TRPV1 and TRPV4 in the esophagus but not with RE or reflux symptoms. Further studies are needed to elucidate the pathogenesis and precise roles of the increased nociceptors.

Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Takeda, N., Takemura, M., Hijikata, H., Fukumitsu, K., Go, J., Nishiyama, H., Kurokawa, R., Kanemitsu, Y., Kubota, E., Kamiya, T., Ueda, T., Niimi, A. Tags: Airway pharmacology and treatment Source Type: research