IL-5/IL-13 drive NLRP3 inflammasome-mediated, steroid-resistant AHR in a model of obesity-associated asthma

Conclusions: Our study highlights an unrecognised role for HFD-induced, obesity-associated, NLRP3 inflammasome responses in steroid-resistant AHR. Furthermore, we identify a novel role for IL-5 and IL-13 responses upstream of the NLRP3 inflammasome in the development of obesity-associated, SSR asthma.

Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Pinkerton, J., Kim, R., Brown, A., Rae, B., Mayall, J., Ali, M. K., Starkey, M., Robertson, A., Wood, L., Cooper, M., ONeill, L., Hansbro, P., Horvat, J. Tags: Allergy and immunology Source Type: research