Features of adipokine regulation at young patients with bronchial asthma with different phenotypes of obesity

Research Objective: Assessment of the level of adipokines and their receptors in blood at young patients with bronchial asthma (BA) depending on the obesity phenotype.Material and Methods: 164 patients with BA were divided into 3 groups: BMI 30-34.9 kg/m2 + thickness of epicardial fatty tissue (EFT) ≥7 mm (1st gr.), BMI 30-34.9 kg/m2 + EFT <7 mm (2nd gr.), BMI 18-24.9 kg/m2 (3rd gr.). Control - 40 almost healthy volunteers. Studied: degree of obesity, parameters of external respiration function, the contents of leptin and adiponectin, and peripheral leptin receptors - ObR and adiponectin - AdipoR1, AdipoR2.Results: in the 1st group the level of leptin was significantly higher, and the level of adiponectin was significant lower than the 2, 3-groups and control. The adiponectin level is inversely correlated with BMI and positive correlations with the maintenance of lipoproteins of high density. Positive correlations between BMI, waist and leptin that proves primary the predominant influence of adipose tissue on the levels of leptin in plasma. The ObR value was statistically significant lower at patients of the 1st group which emphasizes the presence of receptor pathology in severe conditions with high levels of leptin. However, this group was the highest indications of AdipoR2. Marked negative correlations of AdipoR2 with insulin levels, leptin and TNF-α. In total, obviously dispersing phenotypes of obesity confirmed that AdipoR1 and AdipoR2 are functionally excelle...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Allergy and immunology Source Type: research