Cumulative incidence and associated risk factor of chronic pulmonary infection after lung resection surgery for lung cancer

This study is to analyzed Cumulative incidence and associated risk factor of chronic pulmonary infection after lung resection surgery for lung cancerWe retrospectively analyze cumulative incidence and associated risk factor of chronic pulmonary infection for total of 3491 patients who was operated lung resection surgery for lung cancer from January 2010 to December 2014Of the 3,491 patients who underwent surgery for lung cancer, 123 developed chronic pulmonary infection (29 pulmonary tuberculosis, 47 non-tuberculous mycobacterial lung disease, 56 chronic pulmonary aspergillosis, 1 pulmonary actinomycosis). The cumulative incidence at 5 years was 3.9%The risk factors of chronic pulmonary infection were low body mass index(aHR 0.91, 95% CI 0.86-0.97, P=0.003), underlying ILD(aHR 8.97, 95% CI 4.09-19.67, P<0.001), previous history of pul. TB(aHR 2.12, 95% CI 1.37-3.30, P=0.001), Higher stage (aHR 1.686, 95% CI 1.02-2.75, p =0.041 for stage II; aHR 2.40, 95% CI 1.47-3.90, p<0.001 for stage III; aHR 4.90, 95% CI 7.74-13.81, p =0.003 for stage IV), neoadjuvant treatment(aHR 2.57, 95% CI 1.62-4.07, P<0.001), open surgery(aHR 2.40, 95% CI 1.51-3.81, P<0.001), short term post op pulmonary complication within 1 month after surgery(aHR 1.68, 95% CI 1.13-2.50, P=0.011).
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung cancer Source Type: research