The value of immunological methods in the complex diagnostics of TB in chronic renal failure patients in the terminal stage

Conclusions: Immunological tests can be used in complex diagnostics of TB in patients with terminal stage of CRF, but their limitations should be taken into account. Low sensitivity of IGRAs can be explained by insufficient counts of Mtb-specific IFN--producingCD4 lymphocytes. Low specificity of the Mtb-CD27 can be attributed to pronounced inflammation associated with CRF
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Tuberculosis Source Type: research