Predicting the efficiency of the treatment of drug-resistant tuberculosis depending on the polymorphism variation of glutathione-S-transferase genes

Conclusions: The deletion in the promotive area of both genes (GSTT1 0/0 / GSTM1 0/0) increases the risk of no effect of antituberculosis therapy resulting from the cessation of bacterioexcretion by 16.67 times [OR = 24,50, 95% CI OR: 2,18-142 64, p = 0.009]. The presence of mutant isoform GSTM1 genotype in haplotype (GSTT1 + / GSTM1 0 / 0) reduces the chances of effective treatment, which is the lowest with the 240th dose in XDR-TB [OR=0,07, 95%CI OR: 0,09-0,57, p=0,002 and OR=0,37, 95%CI OR: 0,14-0,97, p=0,04].
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Tuberculosis Source Type: research