Prevention of adverse reactions due to pharmacotherapy in MRTB considering polymorphism of glutathione-S-transferase M1 and T1genes

Relevance: Genetics of widespread human diseases is a branch of research which is actively developing. The study of polymorphisms of known candidate genes and their prognostic impact on the disease, is one of the important tasks in the study of tuberculosis.Objective: To prevent the development of adverse reactions due to pharmacotherapy in multi-drug resistant tuberculosis considering deletion polymorphism of the genes in the detoxification system of glutathione-S-transferase xenobiotics.Subject: We have examined 100 patients with newly diagnosed multidrug-resistant uberculosis (MDR-TB).Methods: Polymorphism GSTM1 and GSTM1 areas were isolated using complex multi PCR for M. Arana et all (1996).Results: With null genotype (especially for gene GSTM1) in the haplotype (GSTM1 + / GSTT1 0/0, GSTT1 + / GSTM1 0/0, GSTT1 0/0 / GSTM1 0/0) the development of adverse reactions to the second-line antimycobacterial drugs occurred reliably more frequently by 26,8% (2 = 3,41, p = 0.049) and to the absence of bacterial suspension in the 240th dose by 35.2% (p = 0.006), respectively. In a favorable combination of functional alleles of analyzed genes (GSTM1 + / GSTT1 +) reliably less frequent were nausea and vomiting after taking AMBD, insomnia, dizziness, pain in joints and muscles, itching, rash, headache, edema, fever (p
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Tuberculosis Source Type: research

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'Chinese restaurant syndrome' was coined in the 1960s and refers to headaches, nausea and sweating after eating Chinese food. Campaigners say it's a 'xenophobic myth'.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Source: Journal of Pain Research - Category: Anesthesiology Tags: Journal of Pain Research Source Type: research
ConclusionsBased on a moderate level of certainty, orthodontic patients treated with Invisalign appear to feel lower levels of pain than those treated with fixed appliances during the first few days of treatment. Thereafter (up to 3  months), differences were not noted. Malocclusion complexity level among included studies was mild. Pain is one of many considerations and predictability and technical outcome are more important, mainly considering that the difference does not seem to occur after the first months of the orthodont ic treatment.
Source: Progress in Orthodontics - Category: Dentistry Source Type: research
AbstractOmental flap was introduced for breast reconstruction after mastectomy either alone or as an adjunct to prosthetic reconstruction. Laparoscopically harvested omental flap was used successfully for this issue. Most of reports had described its use after partial mastectomy, skin or nipple areola sparing mastectomies. In this case, we used the thoracodorsal artery perforator (Tdap) flap as a cover for the omental flap in a patient who underwent modified radical mastectomy. Modified radical mastectomy was done in the usual fashion. The descending branch of the thoracodorsal vessel was traced till its main perforator in...
Source: Indian Journal of Surgical Oncology - Category: Cancer & Oncology Source Type: research
I tried searching but couldn't find a relevant thread. I was wondering if anyone has experience with a hospital employed job that compensates in "collections minus expenses." How exactly does this work in a hospital setting? The hospital is still getting the facility fee for each clinic visit (hospital clinic)/procedure - so I'm not really clear on what "expenses" are typically attributed to the physician. Can anyone share their pay structure with this kind of system?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pain Medicine Source Type: forums
ConclusionsUnplanned admissions are more frequently related to general anaesthesia, lengthy surgeries and procedures such as arthroscopy, hallux valgus corrections or removal of osteosynthesis material. The major reasons for unplanned admissions were inadequate postoperative pain management for overnight admissions and wound infection for admissions after discharge.ResumenObjetivoLos procedimientos de Cirugía Ortopédica y Traumatología (COT) realizados en Unidades de Cirugía Mayor Ambulatoria (CMA) ofrecen importantes ventajas que desaparecen cuando la recuperación postoperatoria no es la...
Source: Revista Espanola de Cirugia Ortopedica y Traumatologia - Category: Orthopaedics Source Type: research
Publication date: January–February 2020Source: Revista Española de Cirugía Ortopédica y Traumatología (English Edition), Volume 64, Issue 1Author(s): A. Abarquero-Diezhandino, G. Luengo-Alonso, D. Alonso-Tejero, E.J. Sánchez-Morata, C. Olaya-Gonzalez, J. Vilá y RicoAbstractBackground and aimsAt least 10% of ankle fractures involve the posterior malleolus of the tibia, which has been related to poorer long-term prognosis. Our aim was to analyse the clinical and functional outcomes of ankle fractures involving the posterior edge, treated surgically without direct reduction of t...
Source: Revista Espanola de Cirugia Ortopedica y Traumatologia - Category: Orthopaedics Source Type: research
ConclusionIn the presence of an osteolytic lesion with perilesional oedema in the greater tuberosity, the intraosseous expansion of a calcifying tendinopathy should be included in the differential diagnosis. In our cases the arthroscopic treatment was successful.ResumenAntecedentes y ObjetivoLa tendinitis calcificante del manguito de los rotadores es una de las causas frecuentes de dolor en el hombro. El objetivo fue dar a conocer una presentación poco habitual de la tendinitis calcificante de hombro, la expansión intraósea, que en muchos casos puede ser confundida con una lesión tumoral o infec...
Source: Revista Espanola de Cirugia Ortopedica y Traumatologia - Category: Orthopaedics Source Type: research
ConclusionsThe use of cement in OVF with relative indication led to the same clinical benefit in our sample as those with standard indication. A higher number of leakages occurred in the relative indication group with no clinical consequences or adjacent fractures.ResumenIntroducciónLa cementación vertebral ha demostrado eficacia en mejorar la calidad de vida y el dolor en fracturas vertebrales osteoporóticas (OVF) sin déficit neurológico no susceptibles de tratamiento conservador. Se aconseja emplearla en fracturas recientes, con aplastamiento 50% y>12 meses de evolución de la ...
Source: Revista Espanola de Cirugia Ortopedica y Traumatologia - Category: Orthopaedics Source Type: research
Authors: Cheng W, Li X, Duan J, Zhou Z, Zhou A, Zhao Y, Zeng Y, Chen Y, Cai S, Chen P Abstract The purposes of this study were to: (1) study the prevalence of pain in patients with mild-to-very severe chronic obstructive pulmonary disease (COPD) in China; (2) compare the differences in pain characteristics between stable COPD and acute exacerbation of COPD (AECOPD); (3) explore the clinical associations with pain in those with COPD. This cross-sectional study was conducted in China from October 24, 2017, to January 11, 2019. A face-to-face interview was conducted to collect data. The Chinese version of the brief pa...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - Category: Respiratory Medicine Tags: COPD Source Type: research
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