Predictors of tuberculosis in injection drug users

Conclusion: social vulnerable and comordid IDUs have high risk for TB. They should be screened annually and have an individualized approach for preventing low treatment outcome.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Tuberculosis Source Type: research

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This study aims to explore the relationship between miR-195 and CD40 and its effect on Th17/Treg balance in rats with non-alcoholic fatty liver disease (NAFLD).MethodsWe established rat models of NAFLD and made seven groups, Normal group (without modeling), Model group (model rats), NC group (model rats injected with negative control vector), miR-195 OE group (model rats injected with miR-195 mimic), anti-miR-195 group (model rats injected with miR-195 inhibitor), Si-CD40 group (model rats injected with CD40 silencing vector), and anti-miR-195+Si-CD40 group (model rats injected with miR-195 inhibitor and CD40 silencing vec...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
CONCLUSIONS: Our findings suggest that people who die by suicide while under the influence of alcohol are more likely to be under acute stress (e.g. separation) and not have earlier psychiatric conditions, except substance use. This highlights the importance of more strict alcohol policies, but also the need to improve substance use treatment. PMID: 31973775 [PubMed - in process]
Source: Epidemiology and Psychiatric Sciences - Category: Psychiatry Tags: Epidemiol Psychiatr Sci Source Type: research
We present the case of a patient with partial agenesis of the septum pellucidum who exhibits disorganized behavior and paranoid and persecutory delusions. We add to the literature of incidental neuropsychiatric symptoms in patients with partial agenesis of the septum pellucidum which is an area that requires further exploration and study. We discuss the implications of these findings in light of previous literature findings. PMID: 31976110 [PubMed]
Source: Case Reports in Psychiatry - Category: Psychiatry Tags: Case Rep Psychiatry Source Type: research
Protein kinase C promotes choline transporter‑like protein 1 function via improved cell surface expression in immortalized human hepatic cells. Mol Med Rep. 2020 Feb;21(2):777-785 Authors: Ishikawa T, Suwanai H, Shikuma J, Suzuki R, Yamanaka T, Odawara M, Inazu M Abstract Choline is used to synthesize phospholipids and a lack of choline induces a number of liver‑related diseases, including non‑alcoholic steatohepatitis. The current study characterized the choline uptake system, at molecular and functional levels, in the immortalized human hepatic cell line, Fa2N‑4, to identify the spe...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Identification of hub genes and key pathways of dietary advanced glycation end products‑induced non‑alcoholic fatty liver disease by bioinformatics analysis and animal experiments. Mol Med Rep. 2020 Feb;21(2):685-694 Authors: Wang J, Liu H, Xie G, Cai W, Xu J Abstract Non‑alcoholic fatty liver disease (NAFLD) is a common chronic liver disease. Advanced glycation end products (AGEs) negatively affect the liver and accelerate NAFLD progression; however, the underlying mechanisms remain unclear. The present study aimed to examine the effect and mechanism of dietary AGEs on the mouse liver using bioi...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Authors: Orsini D Abstract Poverty, high population density and unhealthy dwellings in Siena's historic district accounted for the spread of tuberculosis in its various forms between the mid-nineteenth century and the first three decades of the twentieth century. In this paper, the author relies on statistical data relating to a time span between 1898 and 1935 to discuss the high incidence of scrofula, or tuberculosis of the lymphatic glands, among Siena's infant population.The result is a description of the most important actions implemented at city level to prevent tuberculosis and to assist and treat sick childr...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Publication date: Available online 25 January 2020Source: Life SciencesAuthor(s): Wei-Wei Sun, Tao ShangGuan, Ping Zhu, Hua-Kang Li, Min Jiang, Pan Yang, Lin-Yu Li, Zhi-Hui ZhangAbstractAimsNPY-Y1R plays an important role in dietary regulation. Although germline knockdown of NPY-Y1R in mice alleviates high-fat-diet-induced obesity and increases CPT1α levels in the liver, the role of the Y1 receptor in specific tissues has not been studied.Main methodsMCD diet is the most widely used method to establish a model of lean NASH in a short time. We therefore evaluated the role of liver NPY-Y1R in NASH progression.Key findi...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 25 January 2020Source: The Journal of Chemical ThermodynamicsAuthor(s): Seyyed Mohammad Arzideh, Kamyar Movagharnejad, Mohsen PirdashtiAbstractExperimental phase diagrams for {1-butanol/2-butanol/t-butyl alcohol+ potassium hydrogen phosphate (K2HPO4) + water} at 298.15 K have been determined, and their ability to separate an amino acid, L-Tryptophan, were measured. An excess Gibbs energy model has been proposed for modelling of aqueous two-phase systems (ATPS) containing light straight/branched alcohol, K2HPO4, and water. The hybrid ion-interaction and solvation model (HIS) was implemente...
Source: The Journal of Chemical Thermodynamics - Category: Chemistry Source Type: research
Publication date: Available online 22 January 2020Source: Sensors and Actuators B: ChemicalAuthor(s): Ming-Chung Wu, Chih-Kunag Kao, Tz-Feng Lin, Shun-Hsiang Chan, Shih-Hsuan Chen, Chi-Hung Lin, Yu-Ching Huang, Ziming Zhou, Kai Wang, Chao-Sung LaiAbstractVolatile organic compounds (VOCs) are potentially dangerous to the environment and human health. The developed sensing template in this study was prepared by a one-step process on a glass substrate using the electrospinning technique. The sensing material made of the uniaxial aligned CdSe-CdS/Ag/PMMA composite scaffold consists of CdSe-CdS core-shell quantum rods, silver n...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
This study aims to identify the prevalence of preoperative opioid prescriptions and the specialty and practice setting of the prescriber, as well as the percentage of patients who do not report their opioid prescriptions and any variables associated with preoperative opioid prescriptions. METHODS: A total of 461 consecutive new patients evaluated for an arthritic hip or knee were retrospectively studied using institutional data from a tertiary-care, urban center at a university-affiliated private-practice and the state Prescription Monitoring Program to identify opioid prescriptions (including medication, number of pil...
Source: The Journal of the American Academy of Orthopaedic Surgeons - Category: Orthopaedics Tags: J Am Acad Orthop Surg Source Type: research
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