Clinical characteristics and outcomes of surgically resected solitary pulmonary nodules due to nontuberculous mycobacterial infections

Granulomas caused by nontuberculous mycobacterial (NTM) pulmonary infections can present as solitary pulmonary nodules (SPNs) mimicking pulmonary malignancies or other infectious granulomas. However, limited data are available regarding the detailed characteristics and outcomes of surgically resected NTM granulomas. We evaluated the characteristics of 49 surgically resected NTM granulomas presenting as SPNs of 49 patients between January 2007 and December 2016. Twenty-five (51%) were male and 27 (55%) were never-smokers. Seven (14%) patients had histories of tuberculosis and 14 (29%) histories of solid tumors. More than half (51%) of all patients were asymptomatic. On chest computed tomography, the median SPN diameter was 18 mm, and approximately half of all SPNs (49%) were located in the upper lobe. NTM were isolated from sputum (31%), bronchial wash fluid (33%), and biopsy specimens (63%). M. avium (71%, 22/31) was the organism most commonly isolated, followed by M. intracellulare (16%, 5/31). In terms of surgery, wedge resection through video-assisted thoracic surgery (86%, 42/49) was most commonly performed. Postoperative pneumothorax and atelectasis developed in four (8%) and one (2%) patients(s), respectively. Five patients received postoperative antibiotic therapy. Over a median follow-up period of 18 months (interquartile range 5–58 months), NTM pulmonary disease developed in one patient. Most NTM granuloma can be treated safely by surgical resection without pos...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Respiratory infections Source Type: research

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ConclusionAS/AD is a mechanical disorder of the larynx that can be successfully treated if promptly diagnosed. Clinical trials and multi-centric studies are necessary to set management guidelines.
Source: European Archives of Oto-Rhino-Laryngology - Category: ENT & OMF Source Type: research
Authors: Yamaya T, Baba T, Hagiwara E, Ikeda S, Niwa T, Kitayama T, Murohashi K, Higa K, Sato Y, Ogura T Abstract Coronavirus disease 2019 (COVID-19) has been recognized as a worldwide pandemic. However, the clinical course of COVID-19 remains poorly characterized. Although some cases of pneumothorax have been reported, they all had pulmonary complications or were managed with mechanical ventilation. We herein report a case of pneumothorax that developed even though the patient had no pulmonary underlying diseases and had never been managed with mechanical ventilation. In the present case, a lung bulla was found on...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Authors: Kobayashi T, Nakajima K, Oshima Y, Ikeda M, Kitaura S, Ikeuchi K, Okamoto K, Okada Y, Ohama Y, Higurashi Y, Okugawa S, Moriya K Abstract Staphylococcus condimenti is a Gram-positive coccus that was first isolated from soy sauce mash. Only four cases of human S. condimenti infections have been reported to date. We herein report the first case of spondylodiscitis caused by S. condimenti. A 72-year-old Japanese man complaining of lower back pain and numbness in his legs was diagnosed with spondylodiscitis. A computed tomography (CT)-guided biopsy was performed. A culture of the intravertebral disc aspirate yi...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
We report the rare case of a patient co-existing NS and DLBCL. DLBCL might be pathogenesis of NS; the findings are supported by the presence of MN, an underlying malignancy (DLBCL), and the lack of anti-PLA2R antibodies. Although further investigation is warranted, our case suggests that DLBCL is a possible cause of secondary MN. PMID: 33028760 [PubMed - in process]
Source: The Tohoku Journal of Experimental Medicine - Category: Research Authors: Tags: Tohoku J Exp Med Source Type: research
Publication date: Available online 8 October 2020Source: European Journal of RadiologyAuthor(s): Davide Colombi, Marcello Petrini, Gabriele Maffi, Gabriele D. Villani, Flavio C. Bodini, Nicola Morelli, Gianluca Milanese, Mario Silva, Nicola Sverzellati, Emanuele Michieletti
Source: European Journal of Radiology - Category: Radiology Source Type: research
Conclusions: In this multicenter series of 125 APSCDs no injuries to the great vessels/mediastinal structures requiring intervention were identified. Although more than half of patients had evidence of extrinsic vascular compression at the time of injury, careful open reduction of acute injuries can be safely performed. Although vascular injuries following APSCD seem to be quite rare, vascular complications can be catastrophic. Treating providers should consider these data and their own institutional resources to maximize patient safety during the treatment of APSCD. Level of Evidence: Level III—therapeutic case control study.
Source: Journal of Pediatric Orthopaedics - Category: Orthopaedics Tags: Trauma Upper Extremity Source Type: research
Conclusions: Patients undergoing operative management of triplane fractures achieved comparable functional outcomes scores without an increased incidence of complications when compared with patients undergoing nonoperative treatment. Further investigations analyzing outcomes at middle and long-term follow-up are necessary to determine the clinical utility of CT and various treatment modalities for the management of triplane fractures. Level of Evidence: Level IV—Systematic review.
Source: Journal of Pediatric Orthopaedics - Category: Orthopaedics Tags: Trauma Lower Extremity Source Type: research
Study Design. A prospective study of patients originally randomized to total disc replacement (TDR) or multidisciplinary rehabilitation. Objective. To assess the long-term development of facet arthropathy (FA) after TDR versus nonoperative treatment, and to analyze the association between FA and clinical outcome. Summary of Background Data. FA may appear or increase following TDR, but the natural course of FA is unclear, and no previous study has evaluated the long-term development of FA following TDR compared with nonoperative treatment. Methods. The study included 126 patients with chronic low back pain and de...
Source: Spine - Category: Orthopaedics Tags: RANDOMIZED TRIAL Source Type: research
Study Design. Retrospective study. Objective. We identified radiological risk factors for neurological deficits in mid and low lumbar spinal fractures. Summary of Background Data. Although numerous studies have focused on radiological risk factors for neurological deficits in spinal cord injury or thoracolumbar junction area fractures, few have examined mid and low lumbar fractures at the cauda equina level. Methods. We retrospectively reviewed 71 consecutive patients who suffered acute traumatic mid and low lumbar fractures (L2–L5) corresponding to the cauda equina level, as confirmed on magnetic resonanc...
Source: Spine - Category: Orthopaedics Tags: DIAGNOSTICS Source Type: research
Authors: Erbel R Abstract The progress in cardiology during the last 50 years can best be studied by looking at the diagnostics and treatment of patients with aortic valve stenosis. Previously, the clinical examination, electrocardiography (ECG) and chest X‑ray were used before heart catheterization, which included a transseptal puncture to complete the indications for surgery in young patients. Nowadays, echocardiography, often combined with a dobutamine stress test, is the primary diagnostic tool to which computed tomography for quantification of valve calcification and cardiac magnetic resonance...
Source: Herz - Category: Cardiology Tags: Herz Source Type: research
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