Viral prevalence in stable bronchiectasis: analysis of the Cohort of Asian and Matched European Bronchiectasis (CAMEB)

Introduction: The role of viruses in bronchiectasis remains uncertain as detection in stable disease has been previously reported.Aim: To characterise the presence of viral species in the established CAMEB cohort using a panel of RNA viruses.Methods: N=228 airway specimens from CAMEB were subjected to real-time quantitative polymerase chain reaction (RT-qPCR) against a panel of 10 viruses including Coronaviruses (OC43, SARS, NL63, 229E), Parainfluenza viruses (PIV1-4), Rhinovirus and Enterovirus.Results: Virus was detected in N=143 patients (62.7%) with a median viral load of 3.1 x 104 genome copies/g sputum (IQR; 6.6 x 103– 8.2 x 104). The most frequently detected virus was PIV3 in N=135 patients (59.2%) with a median viral load of 2.4 x 104 genome copies/g sputum (IQR; 5.9 x 103– 5.9 x 104) and was commoner in Asians (75% vs 39%, p
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Respiratory infections Source Type: research

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In this study, we evaluated ATA as a potential antiviral drug against ZIKV replication. The antiviral activity of ATA against ZIKV replication in vitro showed median inhibitory concentrations (IC50) of 13.87 ± 1.09 μM and 33.33 ± 1.13 μM in Vero and A549 cells, respectively; without showing any cytotoxic effect in both cell lines (median cytotoxic concentration (CC50)> 1,000 μM). Moreover, ATA protected both cell types from ZIKV-induced cytopathic effect (CPE) and apoptosis in a time- and concentration-dependent manner. In addition, pre-treatment of Vero cells with ATA for up to 72 h also resulted...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Publication date: Available online 17 February 2017 Source:Antiviral Research Author(s): Vathan Kumar, Jin Soo Shin, Jiun-Jie Shie, Keun Bon Ku, Chonsaeng Kim, Yun Young Go, Kai-Fa Huang, Meehyein Kim, Po-Huang Liang Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe acute respiratory illness with fever, cough and shortness of breath. Up to date, it has resulted in 1826 human infections, including 649 deaths. Analogous to picornavirus 3C protease (3Cpro), 3C-like protease (3CLpro) is critical for initiation of the MERS-CoV replication cycle and is thus regarded as a validated drug target. As presented h...
Source: Antiviral Therapy - Category: Virology Source Type: research
Abstract Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe acute respiratory illness with fever, cough and shortness of breath. Up to date, it has resulted in 1826 human infections, including 649 deaths. Analogous to picornavirus 3C protease (3C(pro)), 3C-like protease (3CL(pro)) is critical for initiation of the MERS-CoV replication cycle and is thus regarded as a validated drug target. As presented here, our peptidomimetic inhibitors of enterovirus 3C(pro) (6b, 6c and 6d) inhibited 3CL(pro) of MERS-CoV and severe acute respiratory syndrome coronavirus (SARS-CoV) with IC50 values ranging from ...
Source: Antiviral Research - Category: Virology Authors: Tags: Antiviral Res Source Type: research
Positive-strand RNA (+RNA) viruses are an important group of human and animal pathogens that have significant global health and economic impacts. Notable members include West Nile virus, Dengue virus, Chikungunya, Severe acute respiratory syndrome (SARS) Coronavirus and enteroviruses of the Picornaviridae family.Unfortunately, prophylactic and therapeutic treatments against these pathogens are limited. +RNA viruses have limited coding capacity and thus rely extensively on host factors for successful infection and propagation. A common feature among these viruses is their ability to dramatically modify cellular membranes to...
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research
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