Significance of spirometry lung examination and complete blood count values in patients with asthma, chronic urticaria and Hymenoptera venom allergy
Introduction: In differential diagnosis of allergic diseases, such as asthma, chronic urticaria (CU) and Hymenoptera venom allergy (HVA), the complete blood count (CBC) and spirometry are one of the crucial examinations.Aims and Objectives: To assess the blood lymphocytes, monocytes, basophiles and neutrophils and spirometry parameters in patients with asthma, CU and HVA in comparison to healthy subjects.Methods: The study involved 48 patients with asthma, 19 with CU, 12 with HVA and 17 healthy individuals. Participants had a spirometry and CBC examinations performed.Results: The absolute values of neutrophils were highest in healthy subjects (4,8 G/L). Basophiles and monocytes were highest in asthma (0,06 G/L and 0,59 G/L) while lymphocytes in HVA (2,81 G/L). These parameters were not significantly different in neither of groups in comparison to healthy subjects. However, the Neutrophile% values were significantly lower and Limphocyte% were significantly higher in HVA than in healthy subjects (41,5 % vs 67,0%, p=0,01 and 45,72% vs 24,9%, p
Recent studies have highlighted the multidimensional effect of atopic dermatitis (AD) and urticaria. Patient burden for these conditions is largely driven by the intense itching, sleep disturbance, comorbidities, and mental health illness associated with these diseases.1-3 Immunologic, microbial, and epithelial interactions have been reported to play an important role in AD.4,5 Novel therapies and management approaches are targeting the mechanisms underlying AD and urticaria.6,7 The current issue of the Annals contains 3 outstanding reviews that update readers on the pathophysiology and evolving treatments for AD and chronic urticaria.
Chronic spontaneous urticaria (CSU) is recurrent episodes of urticaria with or without angioedema for 6 weeks or longer due to unknown (nonphysical) causes.1 Although CSU tends to be self-limited in most patients, it has still been shown to markedly affect quality of life.1 The most recent data suggest a 0.5-1% prevalence of CSU in the general population.2 The trigger for CSU is often not known; but there is an association with autoimmune disease.3-5 The treatment includes up to four times (4x) standard dosing of second-generation long-acting H1 antihistamines, short-acting H1 antihistamines, H2 antihistamines, and/or leuk...
Chronic spontaneous urticaria (CSU) involves recurrent episodes of urticaria with or without angioedema for 6 weeks or longer from unknown (nonphysical) causes.1 Although CSU tends to be self-limited in most patients, it still markedly affects quality of life.1 The most recent data suggest a 0.5% to 1% prevalence of CSU in the general population.2 The trigger for CSU is often not known, but there is an association with autoimmune disease.3-5 The treatment includes up to 4 times the standard dosing of second-generation long-acting histamine1 (H1) –antihistamines, short-acting H1-antihistamines, histamine2 (H2)–a...
PMID: 31805358 [PubMed - as supplied by publisher]
PMID: 31761014 [PubMed - in process]
Urticaria is characterized by the appearance of hives or angioedema.1 Chronic urticaria is defined by urticarial episodes that last more than 6 weeks, occurring daily or several times per week.2 Although acute urticaria is commonly associated with infections,3 most cases of chronic urticaria have no identifiable cause. Nevertheless, several reports documented chronic urticaria from infectious causes including Helicobacter pylori.4 Studies show association of upper respiratory infections, including sinusitis, with chronic urticaria with remission after antibiotic therapy.
Conclusions: Among the analysed groups, patients with asthma reached highest BDI score and trait and state anxiety levels. An interesting phenomenon observed in this study, which need further examination, are higher BDI scores in healthy individuals than in CU and HVA groups.This study was financially supported by a grant from Medical University of Lodz (no.564/1-000-00/564-20-026)
AbstractThe European Academy of Allergy and Clinical Immunology (EAACI) supports three journals: Allergy, Paediatric Allergy and Immunology as well as Clinical and Translational Allergy. The major goals of EAACI include (i) supporting health promotion in which the prevention of allergy and asthma plays a critical role and (ii) disseminating the knowledge of allergy to all stakeholders including the EAACI junior members. Substantial progress was made in 2018 in the identification of basic mechanisms of atopic dermatitis and urticaria and the translation of t hese mechanisms into clinics. Many large epidemiologic studi...
A 5-year-old girl with history of significant eczema, severe dog allergy (IgE>100), and anaphylactic allergy to egg and treenuts developed urticaria on her bilateral arms after preparing hamburger patties. No other ingredients, such as egg, were handled. She had previously tolerated cooked beef and had no history of milk allergy.
A 57-year-old female with HIV initially presented for evaluation of lower lip angioedema. Symptoms subjectively waxed and waned over 5-7 day periods but never completely resolved. She denied history of food/medication allergy, urticaria, pruritus, or contact allergy. She had regular HIV follow up and was compliant with antiretroviral therapy (ART). CD4+ lymphocyte counts since presentation ranged from 900-1400 cells/cmm.