Sinonasal sarcoidosis in Iran

Introduction: Sarcoidosis is a granulomatous disease, and about 1-15% of patients with sarcoidosis show sinonasal involvements. Since, sinonasal involvements are similar to non-sarcoid rhinosinusitis and infectious rhinosinusitis and allergies, accurate diagnosis of Sinonasal Sarcoidosis (SNS) patients is mandatory to minimize unnecessary antibiotics and surgical treatments in sarcoidosis patients. This was the first study in Iran, to evaluate the SNS cases and their clinical presentations.Methods: In this cross-sectional study, eighty-eight biopsy proven sarcoidosis patients, with head and neck complaints, were included. All patients underwent the Computed Tomography of Para-nasal Sinuses (CT PNS) and a biopsy sampling through the rhinoscopy. Data were analyzed by Statistical Package for Social Sciences (SPSS) and differences between two groups were obtained with consideration of p-value of
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

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Source: Allergy, Asthma and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Case report Source Type: research
Chronic granulomatous disease (CGD) is a primary immunodeficiency caused by defects in the NADPH oxidase complex, which is responsible for generating the phagocyte respiratory burst. Patients usually present with severe recurrent infections with catalase-positive organisms, and can also have inflammatory disease and autoimmunity.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research
This study assessed omalizumab outcomes in real-world patients with allergic asthma stratified by pretreatment biomarker levels. METHODS: Patients with allergic asthma aged ≥12 years initiated on omalizumab with ≥12 months of data after index were identified in the Allergy Partners electronic medical records (2007-2018). Patients with ≥1 diagnosis of chronic obstructive pulmonary disease in combination with ≥10 pack-years of smoking, cystic fibrosis, Alpha-1 antitrypsin deficiency, bronchiectasis, interstitial lung disease, and sarcoidosis in the 12 months before or after index were excluded. Patients were...
Source: Clinical Therapeutics - Category: Drugs & Pharmacology Authors: Tags: Clin Ther Source Type: research
Abstract Chronic granulomatous disease (CGD) is a rare genetic disorder of neutrophil activity, resulting in increased rate of recurrent infections with catalase-positive bacteria and fungi, as well as various autoimmune diseases such as sarcoidosis, rheumatoid arthritis, and discoid and/or systemic lupus erythematosus. Few reports have reported lupus erythematosus (LE) in patients with X-linked CGD (XL-CGD) and carriers, and very few in autosomal recessive CGD (AR-CGD). Here, we present 5 patients with CGD developing LE at different ages to emphasize on the importance of appropriate follow-up and treatment in pat...
Source: Iranian Journal of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Iran J Allergy Asthma Immunol Source Type: research
Discussion Sarcoidosis is rare and is even rarer in the pediatric age group. Sarcoidosis is seen in all ages with an estimated prevalence is 10-40/100,000 in the U.S. population. Pediatric sarcoidosis has an estimated incidence of 0.2/100,000 per year. For the pediatric age range it is more likely from 9-15 years of age. In adults it commonly presents between 20-39 years but bimodal distribution is also reported. Women are more likely to have sarcoidosis than men. African American females have the highest risk, and usually present slightly older, especially in the 4th decade of life. African American women are also more li...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Conclusions: Although some blood leakage may be involved in the elevation of periostin in the BALF of EP, periostin can be induced locally, at least in part. Therefore, periostin may play a role in the development of EP.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - Category: Allergy & Immunology Source Type: research
Orofacial Granulomatosis (OFG) is a chronic granulomatous condition characterized by persistent or recurring swelling of soft tissues in the face. It is thought to be caused by a delayed hypersensitivity reaction involving a Th1-mediated immune response. There have been reports of cases associated with Sarcoidosis and Crohn's disease.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: M365 Source Type: research
PMID: 30170027 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Ann Allergy Asthma Immunol Source Type: research
is a granulomatous disease of unknown origin that can affect any organ system. It may cause respiratory tract, cardiac, ocular, neurologic, and cutaneous manifestations in isolation or in combination. The cause of sarcoidosis is poorly understood, but because exposure to certain environmental antigens in genetically susceptible individuals can lead to granulomatous inflammation mediated by a predominant T helper-1 (Th1) –mediated response, that mechanism is possible. Several disease clusters have been reported in response to environmental events, such as exposures to industrial chemicals or dust such as observed in ...
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Disease in a Nutshell Source Type: research
Sarcoidosis is a granulomatous disease of unknown etiology which can affect any organ system. It may cause respiratory tract, cardiac, ocular, neurologic, and cutaneous manifestations in isolation or in combination. The etiology of sarcoidosis is poorly understood but since exposure to certain environmental antigens in genetically susceptible individuals can lead to granulomatous inflammation mediated by a predominant T helper-1 (Th1) mediated response, that mechanism is possible. Several disease clusters have been reported in response to environmental events such as exposures to industrial chemicals or dust such as observ...
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Disease in a Nutshell Source Type: research
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