Functional characteristics of children with obesity and asthma

The association between asthma and obesity has been obeserved in many studies but the underlying mechanisms are poorly understood. Aim of the work is to evaluate the respiratory function (forced spirometry, residual volume [RV], DLCO, oscillometry [IOS] and serum concentration of IL-10, IL1-β, TGF-β1, TNF-α, IL-33, adiponectin, leptin in 28 obese non asthmatic children (O+NA) (20 M, median age: 11,7 yrs), compared with 28 obese asthmatic (O+A) and 28 non-obese asthmatic (NO+A), overlapped for sex and age, The results are the following:O+NAMedian (1-3 quartile)O+ANO+AO+NA vs O+AO+NA vs NO+Ap valueO+A vs NO+AVEMS/CVF85(80-89)84(76-89)79(76-82)0,30,00830,23MEF (%)117(103-126)106(91-127)104(94-117)0,120,0180,69RV He (%)214(168-298)209(166-250)272(230-331)0,690,080,0046DLCO25(19-31)26(23-32)26(22-31)0,450,650,66IOS 5Hz11,1(7-14)7(6-10)7,8(6-9)0,00820,00770,73IL-104,6(3-9)4,7(2-12)1,4(0-4)0,760,00520,0047IL-1β63,9(2-158)56(46-133)67,3(63-86)0,480,640,13TGF-β13,7(2-6)52,8(14-91)2,3(1-3)<0,00010,0017<0,0001TNFα3,4(0-88)5,2(3-9)19,8(10-38)0,770,1<0,0001IL-3368,2(45-101)128(96-170)33,7(8-53)0,00120,0006<0,0001ADIPONECTIN14696(9333-20740)16683(9441-23906)20993(13112-32648)0,510,00250,19LEPTIN28,8(21-41)33,1(16-45)1,7(1-5)0,82<0,0001<0,0001O+A and NO+A showed a similar pattern of lung function, except for RV, which is less in O+A. O+NA, even if asympromatic, exhibit a significant increase in peripheral airway resistance. IL-33 and TGF-&be...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Paediatric asthma and allergy Source Type: research