Functional characteristics of children with obesity and asthma

The association between asthma and obesity has been obeserved in many studies but the underlying mechanisms are poorly understood. Aim of the work is to evaluate the respiratory function (forced spirometry, residual volume [RV], DLCO, oscillometry [IOS] and serum concentration of IL-10, IL1-β, TGF-β1, TNF-α, IL-33, adiponectin, leptin in 28 obese non asthmatic children (O+NA) (20 M, median age: 11,7 yrs), compared with 28 obese asthmatic (O+A) and 28 non-obese asthmatic (NO+A), overlapped for sex and age, The results are the following:O+NAMedian (1-3 quartile)O+ANO+AO+NA vs O+AO+NA vs NO+Ap valueO+A vs NO+AVEMS/CVF85(80-89)84(76-89)79(76-82)0,30,00830,23MEF (%)117(103-126)106(91-127)104(94-117)0,120,0180,69RV He (%)214(168-298)209(166-250)272(230-331)0,690,080,0046DLCO25(19-31)26(23-32)26(22-31)0,450,650,66IOS 5Hz11,1(7-14)7(6-10)7,8(6-9)0,00820,00770,73IL-104,6(3-9)4,7(2-12)1,4(0-4)0,760,00520,0047IL-1β63,9(2-158)56(46-133)67,3(63-86)0,480,640,13TGF-β13,7(2-6)52,8(14-91)2,3(1-3)
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Paediatric asthma and allergy Source Type: research

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Publication date: Available online 11 November 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Marcello Cottini, Anita Licini, Carlo Lombardi, Alvise BertiAbstractBackgroundThe involvement of small airways has recently gained greater recognition in asthma. Impulse oscillometry (IOS) is a simple and noninvasive method based on the forced oscillation technique, for the detection of small airway dysfunction (SAD).ObjectiveWe aimed to identify the predictors of SAD in an unselected sample of 400 patients with physician-diagnosed asthma.MethodsAll patients underwent standard spirometry and IOS ...
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
The decline in lung function is observed among asthma and obesity. Measurement of obstructive airway by spirometry is suggested to confirm the diagnosis and monitor treatment outcomes in asthma. Nevertheless, spirometry is hard to complete in preschooler. Impulse oscillometry (IOS) is a new and easier technique to measure airway resistance. We aim to evaluate IOS parameter in Thai asthmatic patients and Thai obese children.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
Conclusion: ACT and miniPAQLQ are complemental to reveal long-standing characteristics: overweight, increased lung volumes and gas trapping, rather than current inflammation or airway obstruction in regularly treated patients.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Paediatric asthma and allergy Source Type: research
Background: Asthma and obesity are common chronic disorders for which the prevalence among children has dramatically increased over the last two decades. Although the presence of lung alterations (restrictive pattern on spirometry) has been demonstrated in the adult obese population, data about respiratory impairment are scant in obese children.Aim: to assess the respiratory function impairment in children with obesity and asthma.Methods: The study included 32 obese subjects (21 with asthma and 11 without asthma), and 10 normal weight and healthy subjects. Subjects were aged 6-16 years. Obesity was defined according to WHO...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Paediatric asthma and allergy Source Type: research
The key treatment for persistent asthma is inhaled corticosteroid (IC). Severe asthmatic patients usually require high doses of IC for long periods of time. High doses of IC may lead to suppression of adrenal and other adverse effects, as obesity
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
Conclusions Most elderly asthmatic patients followed up in our tertiary center were atopic and higher values of total serum IgE suggest atopy. Atopy was inversely correlated with age of asthma onset. The diagnosis of allergic asthma in the elderly population is essential to treat patients more properly, improving their quality of life and decreasing asthma morbidity and mortality.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Conclusion: Obesity has a negative impact on clinical presentation of asthma in children, but we could not find significant alteration in pulmonary functional tests linked with obesity.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Paediatric Asthma and Allergy Source Type: research
Conclusions: The established phenotype of SA for our population was allergic, non-obese children, with normal lung function and variable FeNO.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Paediatric Asthma and Allergy Source Type: research
CONCLUSION: We identified NC as a novel anthropometric index that is strongly correlated with respiratory functions in children. Therefore, close monitoring of respiratory symptoms, particularly in children with obesity and a large NC, could help with early and prompt determination of respiratory complications of obesity. PMID: 28527867 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Ann Allergy Asthma Immunol Source Type: research
Our aim was to study the asthma control achieved in patients with uncontrolled asthma who had received appropriate treatment according to the Global Initiative for Asthma (GINA) 2010 (valid at the time the study was designed), and to analyse the factors associated with a lack of asthma control. This was a multicentre study in routine clinical practice performed in patients with uncontrolled asthma according to GINA 2010. At visit 1, we recorded demographics, asthma characteristics and spirometry. We assessed asthma control using GINA 2010 criteria and the Asthma Control Test (ACT). Treatment was optimised according to GINA...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Asthma and allergy Original Articles: Asthma Source Type: research
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