Aberrant DNA methylation levels of the Formyl Peptide Receptor 1/2/3 genes are associated with obstructive sleep apnea and its clinical phenotypes

Conclusions: FPR1 gene promoter hypomethylation may contribute to prevalent DM in OSA patients probably through up-regulating FPR1/FPR3 expression ratio. FPR2/3 gene promoter hypermethylation may be associated with prevalent hypertension and higher cardiovascular risk probably through down-regulating FPR2/3 expressions, respectively.

Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Chen, Y.-C., Lin, M.-C., Hsu, P.-Y., Su, M.-C., Huang, K.-T., Wang, T.-Y., Lin, Y.-Y. Tags: Sleep and control of breathing Source Type: research