Aberrant DNA methylation levels of the Formyl Peptide Receptor 1/2/3 genes are associated with obstructive sleep apnea and its clinical phenotypes

Conclusions: FPR1 gene promoter hypomethylation may contribute to prevalent DM in OSA patients probably through up-regulating FPR1/FPR3 expression ratio. FPR2/3 gene promoter hypermethylation may be associated with prevalent hypertension and higher cardiovascular risk probably through down-regulating FPR2/3 expressions, respectively.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Sleep and control of breathing Source Type: research

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Abstract Clinical factors associated with daytime sleepiness and insomnia in persons with epilepsy (PWE) were examined in this cross-sectional study of 126 participants (men, 50.8%). Excessive daytime sleepiness (EDS; score of ≥11 on the Epworth Sleepiness Scale (ESS)) was noted in 17.5% of participants (mean score, 6.1 ± 4.2), and moderate-to-severe insomnia (Insomnia Severity Index (ISI) scores of ≥15) was noted in 20.6% (mean score, 7.8 ± 6.4). Linear regression analyses revealed that ESS scores were independently associated with obstructive sleep apnea (OSA; snoring, tiredness, obse...
Source: Epilepsy and Behaviour - Category: Neurology Authors: Tags: Epilepsy Behav Source Type: research
The AASM points to several major warning signs and risk factors for sleep apnea: snoring, choking or gasping, fatigue, obesity and high blood pressure.
Source: WebMD Health - Category: Consumer Health News Source Type: news
Increased frequency of obstructive sleep apnea syndrome in Behçet's syndrome patients with superior vena cava syndrome. Clin Exp Rheumatol. 2019 Nov-Dec;37 Suppl 121(6):132-136 Authors: Gokturk A, Esatoglu SN, Atahan E, Hamuryudan V, Yazici H, Seyahi E Abstract OBJECTIVES: Superior vena cava syndrome (SVCS) is a medical emergency which can also be seen in Behçet's syndrome (BS). Having noted that BS patients with SVCS frequently complained of sleep disturbances, snoring and sleep apnea, suggesting obstructive sleep apnea (OSA), we formally surveyed the risk for OSA among BS patients. ...
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
Patients interested in testing themselves at home for sleep apnea now have a few more options. Earlier this year Itamar Medical Ltd. introduced its third-generation WatchPAT home sleep apnea test (HSAT), the WatchPAT 300, and in June 2019, it debuted WatchPAT ONE, which the company calls the first and only disposable HSAT in the market. This month Blue Shield of California (BSC) and the Blue Cross Blue Shield Federal Employee Plan (BCBS FEP) included WatchPAT as a covered HSAT, Itamar reported in a news release. It added that changes in the U.S. Centers for Medicare &Medicaid Services (CMS) 2020 Fee Schedule are expect...
Source: MDDI - Category: Medical Devices Authors: Tags: Digital Health Source Type: news
Conclusions: Of two commonly used questionnaires to screen for SA, neither the SBQ nor the BQ questionnaire discriminated well between those with or without SA in patients with PAF. Until better screening tools are available PG or PSG needs to be used to detect SA in these patients.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Sleep and control of breathing Source Type: research
This study was conducted among consecutive adults, who were admitted to the Department of Pulmonary Medicine, Marmara University, Istanbul between November 2015 and October 2018. Participants answered the questionnaires and underwent a sleep study with cardiorespiratory polygraphy. OSA was defined as an Apnoe-Hypopnoe-Index (AHI)≥15/h.In all, 1042 adults (334 women; 32.1%) were included. OSA was diagnosed in 589 (56.5%). In the OSA group, women were older (53.7±11.5 vs 47.8± 12.8 yrs; p
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Sleep and control of breathing Source Type: research
Introduction: OSA has a polygraphic definition based on the HAI. It generates nocturnal desaturation responsible for cellular hypoxia with multi-visceral impact mainly cardiac such as arrhythmias.The purpose of our study was to investigate whether peripheral saturation can be a means of descrambling to diagnose OSAS in a population followed for AF.Methods: Analytical prospective study including 100 patients followed for AF. None of the recruited patients had been followed for OSA before. Each patient had a clinical examination and a polygraphy. Patients were divided into 2 groups: G1: with OSA and G2: without OSA.Results: ...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Sleep and control of breathing Source Type: research
CONCLUSION: CPAP indication without a previous sleep study showed a low sensitivity (≅ 22%) but a specificity greater than 95% in patients with high pretest probability for OSA (snoring, report of frequent apneas, BMI> 25 kg/m2 and sleepiness or tiredness plus comorbidity). PMID: 31720981 [PubMed - as supplied by publisher]
Source: Sleep and Breathing - Category: Sleep Medicine Authors: Tags: Sleep Breath Source Type: research
ConclusionCPAP indication without a previous sleep study showed a low sensitivity ( ≅ 22%) but a specificity greater than 95% in patients with high pretest probability for OSA (snoring, report of frequent apneas, BMI> 25 kg/m2 and sleepiness or tiredness plus comorbidity).
Source: Sleep and Breathing - Category: Respiratory Medicine Source Type: research
AbstractOSA is a disease of modernisation. Though many modalities are available for its treatment from invasive to non-invasive; the role of lifestyle modification can never be underrated. Lifestyle modification normally includes walk; diet with less fat; abstinence from alcohol and smoking along with regularising of sleep schedule. However the role of calorie deficit diet along with strength training in OSA has not been extensively researched till date. The present study aimed to evaluate the effect of the calorie deficit diet and strength training in patients with mild to moderate obstructive sleep apnea. It is a prospec...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - Category: ENT & OMF Source Type: research
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