OSA, hypertension, diabetes and dyslipidaemia share common genetic background: Results of a twin study

Purpose: Obstructive sleep apnoea (OSA) is associated with an increased risk for hypertension, diabetes and dyslipidaemia. Both OSA and its comorbidities are at least partly heritable, suggesting a common genetic background for them. Twin studies can help analysing the heritability of OSA and its association with comorbidities.Methods: 47 monozygotic and 22 dizygotic adult twin pairs were recruited from the Hungarian Twin Registry (mean age 51 ± 15 years) who attended an overnight diagnostic polysomnography. Medical history was taken, blood pressure was measured, blood samples were taken for fasting glucose, total cholesterol, triglyceride, HDL-C, LDL-C and lipoprotein (a). For evaluating the heritability of OSA and its comorbidities bivariate analysis was performed with adjustment for age and gender.Results: Significant genetic background has been found for correlations between apnoea-hypopnoea index (AHI) and triglyceride, glucose, systolic- and diastolic blood pressure (SBP, DBP) (all p
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Sleep and control of breathing Source Type: research

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CONCLUSION: Korean patients with OSA frequently had comorbid metabolic syndrome. Moderate to severe OSA during REM sleep may be a predictor of metabolic syndrome. PMID: 31898193 [PubMed - as supplied by publisher]
Source: Sleep and Breathing - Category: Sleep Medicine Authors: Tags: Sleep Breath Source Type: research
ConclusionKorean patients with OSA frequently had comorbid metabolic syndrome. Moderate to severe OSA during REM sleep may be a predictor of metabolic syndrome.
Source: Sleep and Breathing - Category: Respiratory Medicine Source Type: research
Conclusions: Embolism associated with asymptomatic carotid stenosis shows circadian variation with highest rates 4–6 h before midday. This corresponds with peak circadian incidence of stroke and other vascular complications. These and ASED Study results show that monitoring frequency, duration, and time of day are important in ES detection. Introduction Transcranial Doppler (TCD) detected microembolism in the ipsilateral middle cerebral artery (MCA) may help stratify the risk of stroke and other arterial disease complications in persons with advanced (≥60%) asymptomatic carotid stenosis. If so, this techniqu...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Conclusion: Blacks with MetS reported insomnia symptoms and insomnia disorder, use of sleep aids, feeling sleepy during the day, and inadequate sleep durations. The presence of these sleep characteristics suggests that patients with MetS should be referred for further sleep assessment. PMID: 30038481 [PubMed - in process]
Source: Ethnicity and Disease - Category: International Medicine & Public Health Tags: Ethn Dis Source Type: research
Authors: Zhang J, Song Y, Ji Y, Song Y, Cai S, Yu Y, Liu S, Zhang W Abstract The correlation between coronary artery disease (CAD) and obstructive sleep apnea syndrome (OSAS) was investigated to analyze its risk factors. A total of 84 patients with suspected CAD due to chest tightness and pain or nocturnal angina, were selected. They were admitted and received coronary angiography in The Affiliated Hospital of Medical College Qingdao University from March, 2016 to June, 2017. The vital signs were monitored, and the sleep monitoring was performed before and after coronary angiography. Before angiography, the fasting...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Introduction: Metabolic syndrome (MS) is defined as cluster of cardiovascular risk factors: diabetes mellitus, abdominal obesity, high cholesterol and arterial hypertension. Obstructive sleep apnea syndrome (OSA) is considered to be an independent cardiovascular risk factor. Severity of OSA measured by apnea/hypopnea index (AHI) may play an important role in presence of MS and other cardiovascular risk factors. Aim of this study was to evaluate the influence of severity of OSA on presence of MS, other cardiovascular risk factors and atherosclerosis measured by intimomedial thickness of arteria carotis communis (CIMT) in pa...
Source: Sleep Medicine - Category: Sleep Medicine Authors: Tags: Sleep Breathing Disorders Source Type: research
Conclusions: We classified p,p′-DDT and p,p′-DDE as “presumed” to be obesogenic for humans, based on a moderate level of primary human evidence, a moderate level of primary in vivo evidence, and a moderate level of supporting evidence from in vivo and in vitro studies. https://doi.org/10.1289/EHP527 Received: 17 May 2016 Revised: 04 May 2017 Accepted: 09 May 2017 Published: 18 September 2017 Please address correspondence to M.A. La Merrill, Dept. of Environmental Toxicology, University of California, Davis, 1 Shields Ave., 4245 Meyer Hall, Davis, CA 95616-5270 USA. Telephone: (530) 754-7254. E...
Source: EHP Research - Category: Environmental Health Authors: Tags: Review Source Type: research
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians. A 38-year-old woman is evaluated after laboratory study results show an HbA1c value of 9.1%. Her HbA1c goal is less than 7% because she has high function, long life expectancy, few comorbidities, good support, health literacy, and access to care. Medical history is significant for morbid obesity, obstructive sleep apnea, hypertension, and hyperlipidemia. Family history is notable for her mother, sister, and brother with type 2 diabetes, obesity, hypertension, and hyperlipidemia. Medications are insulin g...
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Conditions Diabetes Endocrinology Primary Care Source Type: blogs
ConclusionInsomnia could be associated with hearing impairment in workers who are exposed to occupational noise. Additionally, insomnia may be associated with decreased hearing at low frequencies. Especially, more efforts are required to improve the quality of sleep for workers who are exposed to loud occupational noise. Further well- designed prospective studies are needed to clarify the relationship between insomnia and hearing impairment.
Source: Annals of Occupational and Environmental Medicine - Category: Occupational Health Source Type: research
My 74-year old obese, poorly controlled diabetic patient with high blood pressure, high cholesterol, coronary artery disease, asthma, obstructive sleep apnea has been difficult to motivate to improve his lifestyle and his health. He is bright, sweet and caring but just not very disciplined. At each office visit, we review his medications, review his dietary habits and go through the check list of check-ups for diabetic complications including regular ophthalmology exams and podiatric exams to prevent diabetic retinopathy and foot skin breakdown and infection. His spouse is always present, and we discuss seeing his endocrin...
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Physician Diabetes Emergency Hospital Hospitalist Infectious disease Source Type: blogs
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