The change of PD-1 and CTLA-4 during LTBI and TB reactivation

Conclusions: We preliminarily found that the PD-1 expression were increasing during LTBI status and by contrast, CTLA-4 on CD4 lymphocytes as well as regulatory T cells elevated in TB reactivation. We suggest that the immune modulation pathways of PD-1 and CTLA-4 as well as Treg cells influence different stage of M. tuberculosis infection and needs further investigation for the application in treatment.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Tuberculosis Source Type: research