Detection of NTM in surgery samples from patients hospitalized with presumed TB

TB and mycobacteriosis have similar clinical and radiological manifestations, which can result in a diagnostic error. Introduction of modern methods for diagnosing mycobacterial infections has allowed rapid and precise differentiation between TB and mycobacterioses. It is especially important for surgery patients.The aim of our study was to assess detection of NTM in surgery samples from patients on treatment in hospital at the Central TB Research Institute and assess a spectrum of NTM species.We studied 4440 surgery samples from 3423 patients in 2011-2018. Cultural diagnosis was performed in BACTEC MGIT 960, culture specification was performed using GenoTypeCM/AS (Hain Lifescience, Germany).Of these 4440 surgery samples MGIT positive were 817 samples from 642 patients; M.tuberculosis were isolated from 601/642 (93.61%) patients, NTM – from 41/642 (6.39%) patients. NTM cultures belonged to seven species (see the Table).The retrospective analysis showed that in 64% of NTM-infected surgery patients NTM were detected in sputum at the same time. We should note that identification of species isolated from both sputum and surgery samples provided identical results.Among all MGIT positive patients admitted to hospital with presumed pulmonary TB, NTM was detected in 6.39%.Species identification is important to determine etiology of infection and choose a proper strategy of patient management after surgery.Mycobacterial speciesMGIT positive surgery samplesNumber of samplesNumber...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Tuberculosis Source Type: research