Late Breaking Abstract - B cell adaptive immune profile in emphysema-predominant COPD

Conclusions: The extent of emphysema, and not the severity of airflow limitation, is the strongest predictor of an upregulation of the B cell immune compartment in the lung. A B cell endotype associated with emphysema could define the clinical phenotype (likely emphysema) that could benefit from therapies targeting B cells, leading to earlier and more personalized therapeutic interventions for COPD.

Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Sullivan, J., Bhagevalu, B., Sholl, L., Glass, C., Packard, S., Kraft, M., Martinez, F., De Torres, J. P., Guerra, S., Polverino, F. Tags: Molecular pathology and funct. genomics Source Type: research