Preoperative breast cancer staging with multi-modality imaging and surgical outcomes

Publication date: Available online 22 November 2019Source: European Journal of RadiologyAuthor(s): Giovanna Mariscotti, Manuela Durando, Alberto Tagliafico, Pier Paolo Campanino, Davide Bosco, Cristina Casella, Riccardo Bussone, Ada Ala, Isabella Castellano, Anna Sapino, Laura Bergamasco, Paolo Fonio, Nehmat HoussamiAbstractPurposeTo compare the rates of mastectomy and re-operation after breast-conserving surgery(BCS) among patients who had different pre-operative multi-modality imaging, hence identifying significant predictors of mastectomy and re-operations within each group.MethodRetrospective study of consecutive patients with primary breast cancer treated January2010–December2016, divided in 3 groups, undergoing pre-operative local staging respectively with conventional imaging modalities only (2D mammography, ultrasound (US)), conventional imaging and tomosynthesis (DBT) and/or MRI. The primary outcome was identification of significant predictors of surgical outcomes, within each group. Study variables examined in univariate analysis were age, lesion dimension, breast density, multifocality, tumor size, histology, and if associated with outcomes they were included in binary logistic regression analysis.ResultsAmongst 1547 patients, patient and tumor characteristics differed across the three groups, as did mastectomy rates which were 18% (102/562) for 2D + US, 36% (154/428) for 2D + DBT + US, 45% (250/557) for 2D+/-DBT&thin...
Source: European Journal of Radiology - Category: Radiology Source Type: research

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Targeted therapy using monoclonal antibodies conjugated to toxins is gaining space in the treatment of cancer. Here, we report the anti-tumor effect of a new antibody drug conjugate (ADC) delivering a HDAC inhibitor to ErbB2+ solid tumors. Trastuzumab was partially reduced with tris [2-carboxyethyl] phosphine (TCEP) and conjugated to ST7464AA1, the active form of the prodrug HDAC inhibitor ST7612AA1, through a maleimide-thiol linker to obtain the Antibody Drug Conjugate (ADC) ST8176AA1. The average drug/antibody ratio (DAR) was 4.5 as measured by hydrophobic interaction chromatography (HIC). Binding of ST8176AA1 to ErbB2 r...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Conclusions: The association between aspirin and a reduced risk of esophageal squamous cell carcinoma is supported by strong evidence, researchers and policy makers should pay more attention to the potential merit of repositioning aspirin to prevent esophageal squamous cell carcinoma.
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
ConclusionThe histological nature of SCC seems to bring fundamental new elements to the therapeutic management as it impacts recurrence and survival. It should therefore be better characterized at diagnosis in order to possibly adapt treatments.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
Publication date: Available online 20 January 2020Source: Pathology - Research and PracticeAuthor(s): In Hye Song, Sook-Hee Hong, Kyo Yeong Lee, Jun Kang, Sung Hak Lee, Jieun Lee, Ahwon LeeAbstractDevelopment of molecular technology has led to the expansion of next generation sequencing (NGS) in area of diagnostic pathology. Here we present a case in which a lung tumor, which resembled an atypical carcinoid tumor, was revealed as metastatic breast cancer by next generation sequencing. A 50-year-old female, who had received modified radical mastectomy for breast cancer, presented with a 2.1 cm sized lung mass. The ma...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Publication date: April 2020Source: Biomedicine &Pharmacotherapy, Volume 124Author(s): Zhenya Guo, Yonglian Zeng, Yubing Chen, Mingjiang Liu, Shilian Chen, Mei Yao, Peng Zhang, Fudi Zhong, Keqing Jiang, Songqing He, Guandou YuanAbstractTRAF-interacting protein (TRAIP) is a RING-type E3 ubiquitin ligase which has been implicated in various cellular processes, including NF-κB activation, DNA damage response, mitosis, and tumorigenesis. It is considered as a tumor suppressor in basal cell carcinomas and breast cancer in previous studies. However, in our current study, we found that TRAIP exhibited oncogenic properti...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
ConclusionThis demonstrates procoagulant phenotypic changes occur in fibroblasts at the preinvasive stage. Fibroblast procoagulant phenotype is associated with aggressive breast cancer subtypes and reduced survival. Coagulation may be a therapeutic target in breast cancer.
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Pemphigus is a chronic autoimmune blistering disorder, characterized by (muco-)cutaneous erosions due to autoantibodies against desmoglein 3 and/or 1. Pemphigus induction might be associated with drugs, malignancy or radiation therapy (RT); the latter being only rarely described. A rigorous literature review revealed around 30 cases of RT-associated pemphigus, which had been primarily treated with topical and/or systemic steroids, in some cases also dapsone or few other immunosuppressive agents were given. The most common underlying cancer type was breast cancer. We here present a 63-year-old male patient, who was pre-trea...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Contributors : Girieca Lorusso ; Curzio RueggSeries Type : Expression profiling by arrayOrganism : Mus musculusWe recently established an orthotopic breast cancer model of brain metastasis based on the injection of murine breast cancer cell lines into the mammary fat pad. This model is based on the use of 4T1 murine breast carcinoma cells. 4T1-derived tumors recapitulate the main steps of human breast cancer progression, including epithelial-to-mesenchymal transition and metastases to lung and lymph nodes.Bioluminescence imaging revealed the appearance of secondary lesions to the lung and lymph nodes and sporadically to th...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research
This study demonstrates a comprehensive and cost-effectively scalable one-step rapid bio-fabrication of Eucalyptus globulus leaf extract (ELE) bio-actives functionalized copper oxide nanoparticles (CuONPs) against human breast cancer (MCF-7) cells and Aspergillus flavus. The state-of-art characterization confirmed the thermal-stability of (i) ELE-CuONPs and (ii) surface associated ELE bio-active compounds bearing characteristic functional groups (aromatic-OH, polymeric-OH, C-O, and C = O) over a range of conventional temperatures (30 °C to 80 °C) and microwave (MW) heat (140 °...
Source: Process Biochemistry - Category: Biochemistry Source Type: research
AbstractPurpose of ReviewToday, the term lobular neoplasia (LN) incorporates atypical lobular hyperplasia (ALH), classical lobular carcinoma in situ (C-LCIS) and nonclassical lobular carcinoma in situ (NC-LCIS). These neoplastic lesions are thought of as risk indicators and non-obligate precursors of invasive breast cancer. This review highlights the current literature and up-to-date treatment recommendations for ALH, C-LCIS, and NC-LCIS.Recent FindingsCurrently, NC-LCIS requires surgical excision to rule out a concurrent carcinoma; but a core biopsy diagnosis of ALH or C-LCIS can be safely managed with close clinical and ...
Source: Current Breast Cancer Reports - Category: Cancer & Oncology Source Type: research
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